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应激诱导的半乳糖凝集素-1通过调节CD45免疫反应性淋巴细胞影响脾脏和胸腺中的免疫耐受。

Stress-induced galectin-1 influences immune tolerance in the spleen and thymus by modulating CD45 immunoreactive lymphocytes.

作者信息

Sasaguri Kenichi, Yamada Kentaro, Narimatsu Yuri, Oonuki Masami, Oishi Azusa, Koda Koyo, Kubo Kin-Ya, Yamamoto Toshiharu, Kadoya Toshihiko

机构信息

Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Brain Functions and Neuroscience Division, Department of Oral Science, Kanagawa Dental University Graduate School, Inaoka-cho 82, Yokosuka, Kanagawa, 238-0003, Japan.

出版信息

J Physiol Sci. 2017 Jul;67(4):489-496. doi: 10.1007/s12576-016-0478-8. Epub 2016 Aug 29.

DOI:10.1007/s12576-016-0478-8
PMID:27573167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5487876/
Abstract

Galectin-1 (Gal-1) is differentially expressed in normal and pathological tissues and regulates immune cell homeostasis. Restraint stress increases serum Gal-1 in rats. However, the function of stress-induced Gal-1 in serum is unknown. We determined if stress-induced Gal-1 in serum accumulates in immunocompetent organs as protection from physiological and/or psychological stress. Western blotting showed that the intensity of Gal-1 bands in stressed groups was significantly higher than that in controls. RT-PCR analysis indicated that the Gal-1 mRNA level did not increase after restraint stress. The numbers of Gal-1 immunoreactive cells in the splenic periarterial lymphatic sheath (PLS) and the thymus medulla of the stressed group were increased compared with those in controls. Furthermore, stress-induced Gal-1 immunoreactive cells corresponded to CD45 immunoreactive lymphocytes (CD45) in the PLS of the spleen and the medulla of the thymus. Thus, stress-induced Gal-1 immediately accumulates in the spleen and thymus, and may modulate the immune response through apoptosis by binding to CD45 lymphocytes in immune organs following physiological and/or psychological stress.

摘要

半乳糖凝集素-1（Gal-1）在正常组织和病理组织中存在差异表达，并调节免疫细胞稳态。束缚应激会使大鼠血清中的Gal-1升高。然而，应激诱导血清中的Gal-1的功能尚不清楚。我们研究了应激诱导血清中的Gal-1是否会在免疫活性器官中蓄积，以抵御生理和/或心理应激。蛋白质免疫印迹法显示，应激组中Gal-1条带的强度显著高于对照组。逆转录聚合酶链反应（RT-PCR）分析表明，束缚应激后Gal-1信使核糖核酸（mRNA）水平并未升高。与对照组相比，应激组脾脏动脉周围淋巴鞘（PLS）和胸腺髓质中Gal-1免疫反应性细胞的数量增加。此外，应激诱导的Gal-1免疫反应性细胞与脾脏PLS和胸腺髓质中的CD45免疫反应性淋巴细胞（CD45）相对应。因此，应激诱导的Gal-1会立即在脾脏和胸腺中蓄积，并可能在生理和/或心理应激后通过与免疫器官中的CD45淋巴细胞结合，通过凋亡来调节免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b7/10718002/8be8016dde6d/12576_2016_478_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b7/10718002/2d87010852a4/12576_2016_478_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b7/10718002/e74041ce6020/12576_2016_478_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b7/10718002/2d0bfe70c92a/12576_2016_478_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b7/10718002/b9a02f9c3c4f/12576_2016_478_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b7/10718002/8be8016dde6d/12576_2016_478_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b7/10718002/2d87010852a4/12576_2016_478_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b7/10718002/e74041ce6020/12576_2016_478_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b7/10718002/2d0bfe70c92a/12576_2016_478_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b7/10718002/b9a02f9c3c4f/12576_2016_478_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b7/10718002/8be8016dde6d/12576_2016_478_Fig5_HTML.jpg

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