Derin Narin, Aydin Selcen, Yargiçoglu Piraye, Agar Aysel
Department of Biophysics, Akdeniz University, Faculty of Medicine, Antalya, Turkey.
Int J Neurosci. 2006 Mar;116(3):205-21. doi: 10.1080/00207450690969805.
The purpose of our study was to investigate the effects of L-carnitine on lipid peroxidation, Visual Evoked Potentials (VEPs) and antioxidant enzyme activities such as superoxide dismutase and catalase in rats exposed to chronic restraint stress. Forty male Wistar rats, aged three months were used. They were equally divided into four groups: control (C), the group exposed to restraint stress (R), the group treated with L-carnitine(L) and the group exposed to stress and treated with L-carnitine (RL). Chronic restraint stress was applied for 21 days (1 h/day) and L-carnitine (50 mg/kg/day) was given by gavage to the L and RL groups for the same period. Brain and retina levels of thiobarbituric acid reactive substances (TBARS) were significantly increased in the R group and were not altered in the L group compared to the C group. Brain and retina TBARS levels were lower in the RL group than in the R group. Brain and retina superoxide dismutase and catalase activities were significantly decreased in the L and R groups compared to the C group. L-carnitine pretreatment had no significant effect on superoxide dismutase and catalase activity in the RL group. All latencies of VEP components were prolonged in the R and L groups with respect to the C group. L-carnitine increased the latencies of all VEP components in the L group whereas shortened them in the RL group compared to their control groups. L-carnitine may be a promising agent for the prevention of VEP and TBARS alterations caused by stress.
我们研究的目的是调查左旋肉碱对暴露于慢性束缚应激的大鼠脂质过氧化、视觉诱发电位（VEP）以及超氧化物歧化酶和过氧化氢酶等抗氧化酶活性的影响。使用了40只3个月大的雄性Wistar大鼠。它们被平均分为四组：对照组（C）、暴露于束缚应激的组（R）、用左旋肉碱治疗的组（L）以及暴露于应激并用左旋肉碱治疗的组（RL）。慢性束缚应激持续施加21天（每天1小时），在同一时期，L组和RL组通过灌胃给予左旋肉碱（50毫克/千克/天）。与C组相比，R组大脑和视网膜中硫代巴比妥酸反应性物质（TBARS）水平显著升高，L组则未改变。RL组大脑和视网膜TBARS水平低于R组。与C组相比，L组和R组大脑和视网膜中超氧化物歧化酶和过氧化氢酶活性显著降低。左旋肉碱预处理对RL组超氧化物歧化酶和过氧化氢酶活性没有显著影响。与C组相比，R组和L组所有VEP成分的潜伏期均延长。与各自对照组相比，左旋肉碱使L组所有VEP成分的潜伏期增加，而在RL组则使其缩短。左旋肉碱可能是预防应激引起的VEP和TBARS改变的一种有前景的药物。
