Li Yu-xiu, Pan Shi-hai, Zeng Jing-bo, Yu Kang, Sun Qi, Liu Qiu-ying, Qin Wei, Zhang Qian, Pan Qing-rong, Yu Jian-chun, Xu Tao, Han Shao-mei, Wang Heng
Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhonghua Nei Ke Za Zhi. 2007 Mar;46(3):193-6.
To investigate the effect of a new enteral nutrition suspension (diabetes) (TPF-DM) (Dixson 0.75 kcal/ml) (1 kcal = 4.184 kJ) on blood glucose, serum insulin and lipids as compared with a standard formula (Nutrition MF 0.75 kcal/ml) in patients with type 2 diabetes.
A randomized, controlled, paralleled and single center trial was carried out. A total of 76 patients with type 2 diabetes without using insulin and obvious complications were randomized into a study group and a control group. 36 patients in the study group and 35 in the control group completed the trial. The observation lasted 6 days. All calories came from enteral nutrition. At baseline all the patients had standard mixed meal (bread 50 g, egg 50 g, milk 250 ml, total calorie 400 kcal) test and at the end of the trial a enteral nutrient meal (enteral nutrient 400 ml, total calorie 300 kcal) test. Blood samples were taken before the meal and 30, 60, 120 and 180 minutes after the meal to test plasma glucose, serum insulin, serum lipids and some safety parameters. The area under curve (AUC) for plasma glucose, serum insulin, serum lipids was calculated.
Compared with the mixed meal test, the AUC of plasma glucose and serum insulin during both Dixson 0.75 kcal/ml test and standard formula (Nutrition MF 0.75 kcal/ml) test were significantly lower (P < 0.01). The change at baseline in the study group was more than that in the control group [the change of AUC for plasma glucose (-6.42 +/- 8.62) h x mmol x L(-1) vs (-1.87 +/- 5.30) h x mmol x L(-1), P < 0.01; that of AUC for serum insulin (-36.94 +/- 49.77) h x mIU x L(-1) vs (-18.20 +/- 32.62) h x mIU x L(-1), P < 0.05]. Both the enteral nutrition formula can reduce insulin resistance (calculated by HOMA-IR), but there was no difference between them. There was no significant effect on total cholesterol, high density lipoprotein and low density lipoprotein. AUC of serum triglycerides was lower during the tests with both enteral nutrients than that during mixed meal test, but there was no significant difference between the two groups. There was no safety concern about the enteral nutrition.
Enteral nutrition suspension (diabetes) (TPF-DM) (Dixson 0.75 kcal/ml) is an effective and safe enteral nutrient to be used in patients with type 2 diabetes.
比较一种新型肠内营养混悬液（糖尿病专用）（TPF-DM）（迪信，0.75千卡/毫升）（1千卡 = 4.184千焦）与标准配方（营养MF，0.75千卡/毫升）对2型糖尿病患者血糖、血清胰岛素和血脂的影响。
进行一项随机、对照、平行且单中心的试验。总共76例未使用胰岛素且无明显并发症的2型糖尿病患者被随机分为研究组和对照组。研究组36例患者和对照组35例患者完成了试验。观察持续6天。所有热量均来自肠内营养。在基线时，所有患者均进行标准混合餐（面包50克、鸡蛋50克、牛奶250毫升，总热量400千卡）测试，在试验结束时进行肠内营养餐（肠内营养剂400毫升，总热量300千卡）测试。在餐前以及餐后30、60、120和180分钟采集血样，检测血浆葡萄糖、血清胰岛素、血脂及一些安全参数。计算血浆葡萄糖、血清胰岛素、血脂的曲线下面积（AUC）。
与混合餐测试相比，迪信0.75千卡/毫升测试和标准配方（营养MF，0.75千卡/毫升）测试期间血浆葡萄糖和血清胰岛素的AUC均显著降低（P < 0.01）。研究组基线时的变化大于对照组[血浆葡萄糖AUC的变化为（-6.42±8.62）小时×毫摩尔×升⁻¹ 比 （-1.87±5.30）小时×毫摩尔×升⁻¹，P < 0.01；血清胰岛素AUC的变化为（-36.94±49.77）小时×毫国际单位×升⁻¹ 比 （-18.20±32.62）小时×毫国际单位×升⁻¹，P < 0.05]。两种肠内营养配方均可降低胰岛素抵抗（通过HOMA-IR计算），但两者之间无差异。对总胆固醇、高密度脂蛋白和低密度脂蛋白无显著影响。两种肠内营养剂测试期间血清甘油三酯的AUC均低于混合餐测试期间，但两组之间无显著差异。肠内营养无安全性问题。
肠内营养混悬液（糖尿病专用）（TPF-DM）（迪信，0.75千卡/毫升）是一种用于2型糖尿病患者的有效且安全的肠内营养剂。
