Desai Mina, Gayle Dave, Babu Jooby, Ross Michael G
Department of Obstetrics and Gynecology, David-Geffen School of Medicine at University of California, Los Angeles, CA, USA.
Am J Obstet Gynecol. 2007 Jun;196(6):555.e1-7. doi: 10.1016/j.ajog.2006.11.036.
Modulation of growth of intrauterine growth restricted (IUGR) newborns causes either adult obesity or normalization of body weight and fat. We investigated the impact of rapid versus delayed catch-up growth of IUGR offspring on glucose and lipid profiles.
From 10 days to term gestation and through lactation, control pregnant rats received ad libitum food, whereas study rats were 50% food restricted. Cross-fostering techniques were used to examine effects of food restriction during pregnancy and/or lactation periods. Glucose and lipid profiles were determined in offspring at ages 1 day, 3 weeks, and 9 months.
Food restriction during pregnancy produced hypoglycemic IUGR pups. Those permitted rapid catch-up growth demonstrated adult obesity with insulin resistance (hyperglycemia/hyperinsulinemia) and hypertriglyceridemia. Conversely, IUGR exhibiting delayed catch-up growth demonstrated normal adult body weight and insulin deficiency (hyperglycemia/hypoinsulinemia) and elevated cholesterol levels as compared with controls. However, these adult offspring had higher glucose though similar insulin levels as control offspring nursed by food restricted dam.
The timing and the rate of IUGR newborn catch-up growth causes markedly altered adult phenotypes. Although delayed newborn catch-up growth may be beneficial in the prevention of adult obesity, there may be significant adverse effects on pancreatic function.
调节宫内生长受限（IUGR）新生儿的生长会导致成人肥胖或体重及脂肪正常化。我们研究了IUGR后代快速追赶生长与延迟追赶生长对血糖和血脂谱的影响。
从妊娠10天至足月妊娠并持续至哺乳期，对照孕鼠自由进食，而研究组孕鼠食物限制50%。采用交叉寄养技术来研究孕期和/或哺乳期食物限制的影响。在1日龄、3周龄和9月龄的后代中测定血糖和血脂谱。
孕期食物限制产生了低血糖的IUGR幼崽。那些允许快速追赶生长的幼崽表现出成人肥胖伴胰岛素抵抗（高血糖/高胰岛素血症）和高甘油三酯血症。相反，表现出延迟追赶生长的IUGR幼崽成年后体重正常，但存在胰岛素缺乏（高血糖/低胰岛素血症），与对照组相比胆固醇水平升高。然而，这些成年后代的血糖水平较高，尽管其胰岛素水平与由食物限制的母鼠哺育的对照后代相似。
IUGR新生儿追赶生长的时间和速度会导致明显改变的成年表型。虽然延迟新生儿追赶生长可能有利于预防成人肥胖，但可能对胰腺功能有显著的不良影响。
