Desai Mina, Gayle Dave, Babu Jooby, Ross Michael G
Department of Obstetrics and Gynecology, David-Geffen School of Medicine at University of California Los Angeles, CA, USA.
Am J Obstet Gynecol. 2005 Sep;193(3 Pt 2):1224-32. doi: 10.1016/j.ajog.2005.05.041.
Maternal undernutrition affects fetal growth and development. We investigated whether maternal food restriction during pregnancy and/or lactation permanently alters organ growth among adult offspring.
From 10 days to term gestation and through 21 days lactation, control pregnant rats received ad libitum food, whereas study rats were 50% food restricted. Cross-fostering techniques were used to examine the effects of food restriction during pregnancy and/or lactation periods. Organs were dissected and weighed (percentage of body weight) at ages 3 weeks and 9 months.
Food restriction during pregnancy produced growth-restricted newborns that exhibited catch-up growth that resulted in markedly heavier adult offspring, although with relatively decreased weights of heart, kidney, lung, and brain as compared with controls. Conversely, food restriction during pregnancy/lactation or lactation alone resulted in adult offspring with similar body weights as controls, but with relatively decreased growth of heart and kidney. Males exhibited relatively smaller livers, whereas the females showed relatively smaller adrenal glands.
Sex-dependent, selective, and permanent changes in relative growth of heart and kidney may increase risk of adult diseases.
母体营养不足会影响胎儿的生长发育。我们研究了孕期和/或哺乳期母体食物限制是否会永久性改变成年后代的器官生长。
从妊娠第10天至足月妊娠以及整个21天的哺乳期，对照孕鼠可自由进食，而研究组孕鼠的食物摄入量受限50%。采用交叉寄养技术来研究孕期和/或哺乳期食物限制的影响。在3周龄和9月龄时解剖并称重各器官（占体重的百分比）。
孕期食物限制导致出生时生长受限的新生儿出现追赶生长，成年后代体重显著增加，不过与对照组相比，心脏、肾脏、肺和脑的重量相对减轻。相反，孕期/哺乳期或仅哺乳期食物限制导致成年后代体重与对照组相似，但心脏和肾脏的生长相对减缓。雄性后代肝脏相对较小，而雌性后代肾上腺相对较小。
心脏和肾脏相对生长的性别依赖性、选择性和永久性变化可能会增加成年疾病的风险。
