Monteleone Palmiero, Tortorella Alfonso, Martiadis Vassilis, Serino Ismene, Di Filippo Carmela, Maj Mario
Department of Psychiatry, University of Naples SUN, Naples, Italy.
Neurosci Lett. 2007 Jun 21;421(1):42-6. doi: 10.1016/j.neulet.2007.05.018. Epub 2007 May 22.
Genes involved in serotonin transmission are likely involved in the biological predisposition to bulimia nervosa. We investigated whether the A218C polymorphism of the tryptophan-hydroxylase-1 gene was associated to bulimia nervosa and/or to some phenotypic aspects of the disorder. One hundred eighty Caucasian women (91 patients with bulimia nervosa and 89 healthy controls) were enrolled into the study. They underwent a blood sample collection for A218C polymorphism of the tryptophan-hydroxylase-1 genotyping and a clinical evaluation assessing comorbidity for Axis I and II psychiatric disorders, harm avoidance personality dimension and bulimic symptoms. The distribution of both tryptophan-hydroxylase-1 A218C genotypes and alleles did not significantly differ between patients and controls. Bulimic women with the AA genotype exhibited a more severe binge eating behavior and higher harm avoidance scores than those with CC genotype. These findings support the idea that tryptophan-hydroxylase-1 A218C polymorphism does not play a part in the genetic susceptibility to bulimia nervosa, but it seems to be involved in predisposing bulimic patients to a more disturbed eating behavior and higher harm avoidance.
参与血清素传递的基因可能与神经性贪食症的生物易感性有关。我们研究了色氨酸羟化酶-1基因的A218C多态性是否与神经性贪食症和/或该疾病的某些表型特征相关。180名白种女性（91名神经性贪食症患者和89名健康对照者）被纳入研究。她们接受了血液样本采集以进行色氨酸羟化酶-1基因A218C多态性的基因分型，并接受了一项临床评估，评估轴I和轴II精神疾病的共病情况、避免伤害人格维度和贪食症状。患者和对照者之间色氨酸羟化酶-1 A218C基因型和等位基因的分布没有显著差异。与CC基因型的贪食女性相比，AA基因型的贪食女性表现出更严重的暴饮暴食行为和更高的避免伤害得分。这些发现支持了这样一种观点，即色氨酸羟化酶-1 A218C多态性在神经性贪食症的遗传易感性中不起作用，但它似乎与使贪食症患者出现更紊乱的饮食行为和更高的避免伤害倾向有关。
