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本文引用的文献
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T cells as a self-referential, sensory organ.
Annu Rev Immunol. 2007;25:681-95. doi: 10.1146/annurev.immunol.24.021605.090600.
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Immunity. 2007 Jan;26(1):43-54. doi: 10.1016/j.immuni.2006.10.019. Epub 2006 Dec 21.
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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling.
Nature. 2006 Dec 7;444(7120):724-9. doi: 10.1038/nature05269. Epub 2006 Nov 1.
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Modeling T cell antigen discrimination based on feedback control of digital ERK responses.
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Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.
J Exp Med. 2005 Aug 15;202(4):493-503. doi: 10.1084/jem.20042155. Epub 2005 Aug 8.
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T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.
Nature. 2005 Jul 28;436(7050):578-82. doi: 10.1038/nature03843.
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Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse.
Nat Immunol. 2005 Aug;6(8):785-92. doi: 10.1038/ni1220. Epub 2005 Jun 26.
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T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes.
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