“自身”在T细胞激活中的作用。
A role for "self" in T-cell activation.
作者信息
Krogsgaard Michelle, Juang Jeremy, Davis Mark M
机构信息
Department of Pathology and NYU Cancer Institute, NYU School of Medicine, New York, NY 10016, USA.
出版信息
Semin Immunol. 2007 Aug;19(4):236-44. doi: 10.1016/j.smim.2007.04.003. Epub 2007 Jun 4.
Abstract
The mechanisms by which alphabeta T-cells are selected in the thymus and then recognize peptide MHC (pMHC) complexes in the periphery remain an enigma. Recent work particularly with respect to quantification of T-cell sensitivity and the role of self-ligands in T-cell activation has provided some important clues to the details of how TCR signaling might be initiated. Here, we highlight recent experimental data that provides insights into the initiation of T-cell activation and also discuss the main controversies and uncertainties in this area.
摘要
αβ T细胞在胸腺中被选择，然后在周围组织中识别肽-主要组织相容性复合体（pMHC）的机制仍然是个谜。最近的研究工作，特别是关于T细胞敏感性的量化以及自身配体在T细胞激活中的作用，为TCR信号可能如何启动的细节提供了一些重要线索。在这里，我们重点介绍了最近的实验数据，这些数据为T细胞激活的启动提供了见解，同时也讨论了该领域的主要争议和不确定性。
相似文献
1
A role for "self" in T-cell activation.“自身”在T细胞激活中的作用。
Semin Immunol. 2007 Aug;19(4):236-44. doi: 10.1016/j.smim.2007.04.003. Epub 2007 Jun 4.
2
TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type.胸腺细胞阳性选择启动和完成过程中的TCR信号传导对配体质量和呈递细胞类型有不同的要求。
J Immunol. 2000 Sep 15;165(6):3015-22. doi: 10.4049/jimmunol.165.6.3015.
3
Modulation of T cell function by TCR/pMHC binding kinetics.通过TCR/pMHC结合动力学对T细胞功能进行调节。
Immunobiology. 2006;211(1-2):47-64. doi: 10.1016/j.imbio.2005.09.003. Epub 2006 Jan 4.
4
Self-pMHCII complexes are variably expressed in the thymus and periphery independent of mRNA expression but dependent on the activation state of the APCs.自身pMHCII复合物在胸腺和外周组织中的表达存在差异，其表达不依赖于mRNA表达，但依赖于抗原呈递细胞的激活状态。
Mol Immunol. 2015 Feb;63(2):428-36. doi: 10.1016/j.molimm.2014.09.016. Epub 2014 Oct 22.
5
T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC.短半衰期 pMHC 配体对 T 细胞的拮抗作用可以通过有效捕获 T 细胞向 APC 的极化来介导。
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):210-5. doi: 10.1073/pnas.0911258107. Epub 2009 Dec 14.
6
CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery.CD4 和 CD8 与 MHC 分子的结合主要作用是增强 Lck 的传递。
Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16916-21. doi: 10.1073/pnas.1010568107. Epub 2010 Sep 13.
7
Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands.通过自身肽-主要组织相容性复合体配体对T细胞反应性进行动态调节。
J Exp Med. 2001 May 21;193(10):1179-87. doi: 10.1084/jem.193.10.1179.
8
9
CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation.表达高亲和力T细胞受体的CD8（-）T细胞转染子表现出增强的肽依赖性激活。
J Exp Med. 2001 Oct 15;194(8):1043-52. doi: 10.1084/jem.194.8.1043.
10
T cells as a self-referential, sensory organ.作为一种自我参照的感觉器官的T细胞。
Annu Rev Immunol. 2007;25:681-95. doi: 10.1146/annurev.immunol.24.021605.090600.
引用本文的文献
1
Remote Force Modulation of the T-Cell Receptor Reveals an NFAT-Threshold for CD4 T-Cell Activation.T细胞受体的远程力调节揭示了CD4 T细胞激活的NFAT阈值。
Eur J Immunol. 2025 Jun;55(6):e51716. doi: 10.1002/eji.202451716.
2
Learning from Persistent Viremia: Mechanisms and Implications for Clinical Care and HIV-1 Cure.从持续性病毒血症中学习：机制及对临床护理和 HIV-1 治愈的启示。
Curr HIV/AIDS Rep. 2023 Dec;20(6):428-439. doi: 10.1007/s11904-023-00674-w. Epub 2023 Nov 13.
3
Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation.四跨膜蛋白 5 介导的 MHC Ⅰ类分子簇集对于最佳 CD8+T 细胞激活是必需的。
Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2122188119. doi: 10.1073/pnas.2122188119. Epub 2022 Oct 10.
4
Docking of Syk to FcεRI is enhanced by Lyn but limited in duration by SHIP1.Syk 与 FcεRI 的对接由 Lyn 增强，但受 SHIP1 限制持续时间。
Mol Biol Cell. 2022 Sep 1;33(10):ar89. doi: 10.1091/mbc.E21-12-0603. Epub 2022 Jul 6.
5
Coreceptors and TCR Signaling - the Strong and the Weak of It.共受体与T细胞受体信号传导——其强与弱
Front Cell Dev Biol. 2020 Oct 16;8:597627. doi: 10.3389/fcell.2020.597627. eCollection 2020.
6
Strategies to Address Chimeric Antigen Receptor Tonic Signaling.应对嵌合抗原受体共刺激信号的策略。
Mol Cancer Ther. 2018 Sep;17(9):1795-1815. doi: 10.1158/1535-7163.MCT-17-1097.
7
Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.非刺激肽-MHC 通过放大 TCR 信号转导增强人类 T 细胞抗原特异性反应。
Nat Commun. 2018 Jul 13;9(1):2716. doi: 10.1038/s41467-018-05288-0.
8
CART cells are prone to Fas- and DR5-mediated cell death.嵌合抗原受体 T 细胞易于 Fas 和 DR5 介导的细胞死亡。
J Immunother Cancer. 2018 Jul 13;6(1):71. doi: 10.1186/s40425-018-0385-z.
9
Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation.开发一种用于筛选 T 细胞受体信号和 T 细胞激活的新型调节剂的筛选策略。
Sci Rep. 2018 Jul 3;8(1):10046. doi: 10.1038/s41598-018-28106-5.
10
HCV T Cell Receptor Chain Modifications to Enhance Expression, Pairing, and Antigen Recognition in T Cells for Adoptive Transfer.丙型肝炎病毒T细胞受体链修饰，以增强T细胞中用于过继转移的表达、配对和抗原识别。
Mol Ther Oncolytics. 2017 May 17;5:105-115. doi: 10.1016/j.omto.2017.05.004. eCollection 2017 Jun 16.
本文引用的文献
1
T cells as a self-referential, sensory organ.作为一种自我参照的感觉器官的T细胞。
Annu Rev Immunol. 2007;25:681-95. doi: 10.1146/annurev.immunol.24.021605.090600.
2
Full activation of the T cell receptor requires both clustering and conformational changes at CD3.T细胞受体的完全激活需要CD3处的聚集和构象变化。
Immunity. 2007 Jan;26(1):43-54. doi: 10.1016/j.immuni.2006.10.019. Epub 2006 Dec 21.
3
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling.由Ras/丝裂原活化蛋白激酶信号通路的分隔所定义的胸腺选择阈值。
Nature. 2006 Dec 7;444(7120):724-9. doi: 10.1038/nature05269. Epub 2006 Nov 1.
4
Modeling T cell antigen discrimination based on feedback control of digital ERK responses.基于数字ERK反应的反馈控制对T细胞抗原识别进行建模。
PLoS Biol. 2005 Nov;3(11):e356. doi: 10.1371/journal.pbio.0030356. Epub 2005 Oct 25.
5
Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.多价和单价TCR的共存解释了高敏感性和广泛的反应范围。
J Exp Med. 2005 Aug 15;202(4):493-503. doi: 10.1084/jem.20042155. Epub 2005 Aug 8.
6
T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.T细胞受体的触发严重依赖于其肽-MHC配体的尺寸。
Nature. 2005 Jul 28;436(7050):578-82. doi: 10.1038/nature03843.
7
Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse.非刺激性肽在免疫突触处促进抗原诱导的CD8-T细胞受体相互作用。
Nat Immunol. 2005 Aug;6(8):785-92. doi: 10.1038/ni1220. Epub 2005 Jun 26.
8
CD8+ cytotoxic T lymphocyte activation by soluble major histocompatibility complex-peptide dimers.可溶性主要组织相容性复合体 - 肽二聚体激活CD8 + 细胞毒性T淋巴细胞
J Biol Chem. 2005 Jun 24;280(25):23820-8. doi: 10.1074/jbc.M500654200. Epub 2005 Mar 31.
9
T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes.肽-MHC配体与T细胞受体结合会诱导胸腺细胞CD3复合物发生构象变化。
J Exp Med. 2005 Feb 21;201(4):517-22. doi: 10.1084/jem.20042036.
10
Twisting tails exposed: the evidence for TCR conformational change.扭转尾巴暴露：TCR构象变化的证据
J Exp Med. 2005 Feb 21;201(4):489-92. doi: 10.1084/jem.20050179.
Zotero 插件