流感嗜血杆菌的脂蛋白e（P4）：在血红素利用和发病机制中的作用。
Lipoprotein e (P4) of Haemophilus influenzae: role in heme utilization and pathogenesis.
作者信息
Morton Daniel J, Smith Ann, VanWagoner Timothy M, Seale Thomas W, Whitby Paul W, Stull Terrence L
机构信息
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
出版信息
Microbes Infect. 2007 Jul;9(8):932-9. doi: 10.1016/j.micinf.2007.03.013. Epub 2007 Apr 5.
Abstract
Lipoprotein e (P4) of Haemophilus influenzae is a phosphomonoesterase, encoded by the hel gene, that has been implicated in the acquisition of heme by this fastidious organism. However, lipoprotein e (P4) is also involved in the utilization of NAD and NMN. Some reports have concluded that the reported heme-related growth defect actually reflects a growth defect for NAD. In the current study, hel insertion mutants were constructed and a role for e (P4) in heme acquisition was demonstrated independent of its role in NAD or NMN acquisition. In addition, a rat model of infection demonstrated a role for e (P4) in the pathogenesis of invasive disease.
摘要
流感嗜血杆菌的脂蛋白e（P4）是一种磷酸单酯酶，由hel基因编码，这种挑剔的生物体获取血红素的过程与之有关。然而，脂蛋白e（P4）也参与烟酰胺腺嘌呤二核苷酸（NAD）和烟酰胺单核苷酸（NMN）的利用。一些报告得出结论，所报道的与血红素相关的生长缺陷实际上反映了NAD的生长缺陷。在当前的研究中，构建了hel插入突变体，并证明了e（P4）在血红素获取中的作用独立于其在NAD或NMN获取中的作用。此外，一个大鼠感染模型证明了e（P4）在侵袭性疾病发病机制中的作用。
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