Barnes M S, Bonham M P, Robson P J, Strain J J, Lowe-Strong A S, Eaton-Evans J, Ginty F, Wallace J M W
Northern Ireland Centre for Food and Health (NICHE), University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK.
Mult Scler. 2007 Jun;13(5):670-2. doi: 10.1177/1352458506072666. Epub 2007 Feb 16.
Populations with insufficient ultraviolet exposure and who consume diets low in vitamin D have low vitamin D status (plasma 25-hydroxyvitamin D (25(OH)D) concentrations) and a reported higher incidence of multiple sclerosis (MS). The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is an effective anti-inflammatory molecule. No research to date has assessed 1,25(OH)2D3 concentrations in individuals with MS. In this study, plasma concentrations of 25(OH)D, 1,25(OH)2D3 and parathyroid hormone (PTH) were measured in 29 individuals with MS and 22 age- and sex-matched control volunteers. There were no significant differences in plasma PTH, 25(OH)D and 1,25(OH)2D3 concentrations between individuals with MS and control volunteers. Women with MS had significantly higher 25(OH)D and 1,25(OH)2D3 concentrations than men with MS (79.1+/-45.4 versus 50.2+/-15.3 nmol/L, P=0.019 and 103.8+/-36.8 versus 70.4+/-28.7 pmol/L, P=0.019, respectively). There was a significant positive correlation between 25(OH)D and 1,25(OH)2D3 concentrations in all subjects (r=0.564, P=0.000), but secondary analysis revealed that the correlation was driven by women with MS (r=0.677, P=0.001). Significant sex differences in vitamin D metabolism were observed and were most marked in individuals with MS, suggesting that vitamin D requirements may differ between the sexes, as well as by underlying disease state.
紫外线照射不足且饮食中维生素D含量低的人群维生素D水平较低（血浆25-羟基维生素D（25(OH)D）浓度），且据报道多发性硬化症（MS）发病率较高。维生素D的活性形式1,25-二羟基维生素D3（1,25(OH)2D3）是一种有效的抗炎分子。迄今为止，尚无研究评估MS患者体内1,25(OH)2D3的浓度。在本研究中，对29例MS患者和22名年龄及性别匹配的对照志愿者测定了血浆25(OH)D、1,25(OH)2D3和甲状旁腺激素（PTH）的浓度。MS患者与对照志愿者之间的血浆PTH、25(OH)D和1,25(OH)2D3浓度无显著差异。患有MS的女性的25(OH)D和1,25(OH)2D3浓度显著高于患有MS的男性（分别为79.1±45.4与50.2±15.3 nmol/L，P = 0.019；103.8±36.8与70.4±28.7 pmol/L，P = 0.019）。所有受试者的25(OH)D和1,25(OH)2D3浓度之间存在显著正相关（r = 0.564，P = 0.000），但二次分析显示这种相关性是由患有MS的女性驱动的（r = 0.677，P = 0.001）。观察到维生素D代谢存在显著的性别差异，在MS患者中最为明显，这表明维生素D需求可能因性别以及潜在疾病状态而异。
