Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam University Medical Center, 1081 HV Amsterdam, The Netherlands.
Department of Internal Medicine, Amsterdam UMC, Amsterdam University medical Center, 1081 HV Amsterdam, The Netherlands.
Nutrients. 2019 Nov 15;11(11):2774. doi: 10.3390/nu11112774.
Vitamin D (VitD) insufficiency is common in multiple sclerosis (MS). VitD has possible anti-inflammatory effects on the immune system. The ratio between VitD metabolites in MS patients and the severity of the disease are suggested to be related. However, the exact effect of the bone-derived hormone fibroblast-growth-factor-23 (FGF23) and VitD binding protein (VDBP) on this ratio is not fully elucidated yet. Therefore, the aim is to study differences in total, free, and bioavailable VD metabolites and FGF23 between MS patients and healthy controls (HCs). FGF23, vitD (25(OH)D), active vitD (1,25(OH)D), inactive 24,25(OH)D, and VDBP were measured in 91 MS patients and 92 HCs. Bioavailable and free concentrations were calculated. No difference in FGF23 ( = 0.65) and 25(OH)D/24.25(OH)D ratio ( = 0.21) between MS patients and HCs was observed. Bioavailable 25(OH)D and bioavailable 1.25(OH)D were lower ( < 0.01), while VDBP concentrations were higher in MS patients ( = 0.02) compared with HCs, specifically in male MS patients ( = 0.01). In conclusion, FGF23 and 25(OH)D/24.25(OH)D did not differ between MS patients and HCs, yet bioavailable VitD concentrations are of potential clinical relevance in MS patients. The possible immunomodulating role of VDBP and gender-related differences in the VD-FGF23 axis in MS need further study.
维生素 D（VitD）不足在多发性硬化症（MS）中很常见。VitD 对免疫系统可能具有抗炎作用。MS 患者 VitD 代谢物与疾病严重程度之间的比例关系被认为存在关联。然而，骨源性激素成纤维细胞生长因子 23（FGF23）和 VitD 结合蛋白（VDBP）对该比例的确切影响尚未完全阐明。因此，本研究旨在研究 MS 患者与健康对照者（HCs）之间总 VitD 代谢物、游离 VitD 代谢物和生物可利用 VitD 代谢物以及 FGF23 的差异。共测量了 91 名 MS 患者和 92 名 HCs 的 FGF23、vitD（25（OH）D）、活性 vitD（1,25（OH）D）、非活性 24,25（OH）D 和 VDBP。计算了生物可利用浓度和游离浓度。MS 患者和 HCs 之间的 FGF23（ = 0.65）和 25（OH）D/24.25（OH）D 比值（ = 0.21）无差异。生物可利用 25（OH）D 和生物可利用 1,25（OH）D 水平较低（<0.01），而 VDBP 浓度在 MS 患者中较高（ = 0.02），特别是在男性 MS 患者中（ = 0.01）。总之，MS 患者和 HCs 之间的 FGF23 和 25（OH）D/24.25（OH）D 无差异，但生物可利用 VitD 浓度在 MS 患者中具有潜在的临床相关性。VDBP 的可能免疫调节作用以及 MS 中 VitD-FGF23 轴的性别相关差异需要进一步研究。
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