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本文引用的文献

1
Spectrum and potency of dalbavancin tested against 3322 Gram-positive cocci isolated in the United States Surveillance Program (2004).在美国监测项目（2004年）中分离出的3322株革兰氏阳性球菌上测试的达巴万星的抗菌谱和效价。
Diagn Microbiol Infect Dis. 2006 Feb;54(2):149-53. doi: 10.1016/j.diagmicrobio.2005.08.015. Epub 2006 Jan 19.
2
Population pharmacokinetic analysis of dalbavancin, a novel lipoglycopeptide.新型脂糖肽类药物达巴万星的群体药代动力学分析
J Clin Pharmacol. 2005 Nov;45(11):1279-87. doi: 10.1177/0091270005280378.
3
Randomized, double-blind comparison of once-weekly dalbavancin versus twice-daily linezolid therapy for the treatment of complicated skin and skin structure infections.每周一次达巴万星与每日两次利奈唑胺治疗复杂性皮肤及皮肤结构感染的随机双盲比较
Clin Infect Dis. 2005 Nov 15;41(10):1407-15. doi: 10.1086/497271. Epub 2005 Oct 6.
4
Human pharmacokinetics and rationale for once-weekly dosing of dalbavancin, a semi-synthetic glycopeptide.人用达巴万星（一种半合成糖肽类抗生素）的药代动力学及每周一次给药的理论依据。
J Antimicrob Chemother. 2005 Mar;55 Suppl 2:ii25-30. doi: 10.1093/jac/dki008.
5
Antistaphylococcal activity of dalbavancin, an experimental glycopeptide.达巴万星（一种实验性糖肽）的抗葡萄球菌活性
Antimicrob Agents Chemother. 2005 Feb;49(2):770-2. doi: 10.1128/AAC.49.2.770-772.2005.
6
Antibiotic treatment of gram-positive bone and joint infections.革兰氏阳性菌所致骨与关节感染的抗生素治疗
J Antimicrob Chemother. 2004 Jun;53(6):928-35. doi: 10.1093/jac/dkh191. Epub 2004 Apr 29.
7
Worldwide assessment of dalbavancin activity and spectrum against over 6,000 clinical isolates.达巴万星对6000多株临床分离株的活性和抗菌谱的全球评估。
Diagn Microbiol Infect Dis. 2004 Feb;48(2):137-43. doi: 10.1016/j.diagmicrobio.2003.09.004.
8
Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997-1999.葡萄球菌属感染调查：1997 - 1999年美国、加拿大、拉丁美洲、欧洲及西太平洋地区为哨兵抗菌监测计划收集的分离株的发生频率及抗菌药敏情况
Clin Infect Dis. 2001 May 15;32 Suppl 2:S114-32. doi: 10.1086/320184.
9
Efficacy of teicoplanin and autoradiographic diffusion pattern of [14C]teicoplanin in experimental Staphylococcus aureus infection of joint prostheses.替考拉宁在人工关节假体金黄色葡萄球菌感染实验中的疗效及[14C]替考拉宁的放射自显影扩散模式
Antimicrob Agents Chemother. 1998 Nov;42(11):2830-5. doi: 10.1128/AAC.42.11.2830.

给新西兰白兔注射[14C]达巴万星后，放射性在骨骼及相关结构中的分布情况。

Distribution of radioactivity in bone and related structures following administration of [14C]dalbavancin to New Zealand white rabbits.

作者信息

Solon Eric G, Dowell James A, Lee Jonghui, King S Peter, Damle Bharat D

机构信息

Quest Pharmaceuticals Services, Newark, DE, USA.

出版信息

Antimicrob Agents Chemother. 2007 Aug;51(8):3008-10. doi: 10.1128/AAC.00020-07. Epub 2007 Jun 4.

DOI:10.1128/AAC.00020-07
PMID:17548492
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1932505/
Abstract

Penetration of dalbavancin into noninfected bone and joint tissues was assessed after an intravenous dose of 20 mg/kg (of body weight) [(14)C]dalbavancin given to rabbits. Drug-derived radioactivity, determined over 14 days by either liquid scintillation counting or autoradiography, remained above the MIC for common gram-positive pathogens that cause bone and joint infections.

摘要

在给兔子静脉注射20mg/kg（体重）的[¹⁴C]达巴万星后，评估了达巴万星在未感染的骨和关节组织中的渗透情况。通过液体闪烁计数或放射自显影在14天内测定的药物衍生放射性，对于引起骨和关节感染的常见革兰氏阳性病原体而言，仍高于最低抑菌浓度。