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[18F] -氟脱氧葡萄糖([18F] -FDG)成像在结节病中的影响:[18F] -FDG正电子发射断层扫描(PET)发现的隐匿性神经结节病以及对皮质类固醇治疗的早期代谢反应

Impact of [18F]-fluorodeoxyglucose ([18F]-FDG) imaging in sarcoidosis: unsuspected neurosarcoidosis discovered by [18F]-FDG PET and early metabolic response to corticosteroid therapy.

作者信息

Aide N, Benayoun M, Kerrou K, Khalil A, Cadranel J, Talbot J N

机构信息

Hôpitaux de Paris PET centre, Department of Radiology, Paris, France.

出版信息

Br J Radiol. 2007 Mar;80(951):e67-71. doi: 10.1259/bjr/33076108.

DOI:10.1259/bjr/33076108
PMID:17548505
Abstract

A 46-year-old woman, with biopsy proven pulmonary sarcoidosis, was referred for an [18F]-FDG PET/CT scan that depicted multivisceral involvement and an unusual [18F]-FDG focus located in the pituitary fossa consistent with pituitary sarcoidosis. This was confirmed by decreased antidiuretic hormone blood levels and contrast-enhanced CT scan. This unsuspected neurosarcoidosis prompted corticosteroid therapy. A [18F]-FDG-PET/CT examination performed 10 weeks after initiation of treatment revealed complete recovery. It is suggested that the skull base should be included in the PET scanning of patients with sarcoidosis. [18F]-FDG imaging may be useful in the early evaluation of response to treatment.

摘要

一名46岁女性,经活检证实患有肺部结节病,因进行[18F]-FDG PET/CT扫描前来就诊,扫描显示多脏器受累,且垂体窝有一个异常的[18F]-FDG浓聚灶,符合垂体结节病。抗利尿激素血水平降低及增强CT扫描证实了这一点。这种未被怀疑的神经结节病促使进行了皮质类固醇治疗。治疗开始10周后进行的[18F]-FDG-PET/CT检查显示完全恢复。建议结节病患者的PET扫描应包括颅底。[18F]-FDG成像可能有助于早期评估治疗反应。

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