图雷特综合征患者抽动产生所涉及神经回路的神经影像学研究
Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome.
作者信息
Lerner A, Bagic A, Boudreau E A, Hanakawa T, Pagan F, Mari Z, Bara-Jimenez W, Aksu M, Garraux G, Simmons J M, Sato S, Murphy D L, Hallett M
机构信息
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-2035, USA.
出版信息
Neurology. 2007 Jun 5;68(23):1979-87. doi: 10.1212/01.wnl.0000264417.18604.12.
OBJECTIVE
To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline.
METHODS
We used [15O]H2O PET to study nine patients with Tourette syndrome and nine matched control subjects. For patients, conditions included tic release states and sleep stage 2; and for control subjects, rest states and sleep stage 2.
RESULTS
Our study showed robust activation of cerebellum, insula, thalamus, and putamen during tic release.
CONCLUSION
The network of structures involved in tics includes the activated regions and motor cortex. The prominent involvement of cerebellum and insula suggest their involvement in tic initiation and execution.
目的
以睡眠作为基线，确定抽动秽语综合征患者产生抽动的脑区。
方法
我们使用[15O]H2O正电子发射断层扫描（PET）研究了9例抽动秽语综合征患者和9名匹配的对照受试者。对于患者，条件包括抽动缓解状态和睡眠2期；对于对照受试者，条件包括静息状态和睡眠2期。
结果
我们的研究显示，在抽动缓解期间，小脑、脑岛、丘脑和壳核有强烈激活。
结论
参与抽动的结构网络包括激活区域和运动皮层。小脑和脑岛的显著参与表明它们参与了抽动的起始和执行。
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