Hohlfeld Reinhard, Kerschensteiner Martin, Meinl Edgar
Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University, Klinikum Grosshadern, Munich, Germany.
Neurology. 2007 May 29;68(22 Suppl 3):S58-63; discussion S91-6. doi: 10.1212/01.wnl.0000275234.43506.9b.
Inflammatory responses in the CNS have usually been perceived to cause or contribute to neuron injury. However, emerging evidence suggests that inflammatory reactions can also be neuroprotective. The nervous and immune systems employ overlapping mechanisms and shared mediators that promote cross-talk between the two systems. Immune cells, for example, produce not only neurodestructive molecules but also factors that can support neuroaxonal growth, survival, and plasticity. This might explain why inflammatory reactions may contribute to both injury and protection of neurons. The dual role of CNS inflammation also has important therapeutic implications that are only beginning to be explored.
中枢神经系统中的炎症反应通常被认为会导致或促成神经元损伤。然而，新出现的证据表明，炎症反应也可以具有神经保护作用。神经和免疫系统采用重叠的机制和共享的介质来促进两个系统之间的相互作用。例如，免疫细胞不仅产生具有神经破坏作用的分子，还产生能够支持神经轴突生长、存活和可塑性的因子。这或许可以解释为什么炎症反应可能对神经元的损伤和保护都有影响。中枢神经系统炎症的双重作用也具有重要的治疗意义，而这才刚刚开始被探索。
