Nielson Carrie M, Flores Roberto, Harris Robin B, Abrahamsen Martha, Papenfuss Mary R, Dunne Eileen F, Markowitz Lauri E, Giuliano Anna R
Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health, Tucson, Arizona, USA.
Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1107-14. doi: 10.1158/1055-9965.EPI-06-0997.
Human papillomavirus (HPV) is sexually transmitted and causes cervical cancer. Although HPV can infect men and women, little is known about infection in men. Specifically, the prevalence of type-specific HPV infection and the distribution of infections by anogenital anatomic site in men are incompletely characterized.
We tested 463 men ages 18 to 40 years for HPV at the glans/corona, penile shaft, scrotum, urethra, perianal area, anal canal, and in a semen sample. Eligible men acknowledged no history of genital warts and had sexual intercourse with a woman within the past year. HPV testing by PCR and reverse line blot genotyping for 37 types was conducted on each of the specimens from the seven sampling sites.
When HPV results from any sampling site were considered, 237 (51.2%) men were positive for at least one oncogenic or nononcogenic HPV type, and another 66 (14.3%) men were positive for an unclassified HPV type. The types with the highest prevalence were HPV-16 (11.4%) and 84 (10.6%). External genital samples (glans/corona, shaft, and scrotum) were more likely than anal samples to contain oncogenic HPV (25.1% versus 5.0%). HPV-positive penile shaft and glans/corona samples were also more likely to be infected with multiple HPV types than other sites.
More complete anogenital sampling and sensitive detection for 37 HPV types resulted in a higher HPV prevalence in primarily asymptomatic men than reported previously. The penile shaft was the site most likely to be HPV positive and harbored the greatest proportion of multiple type and oncogenic infections. These results have implications for research of HPV among men and transmission between partners.
人乳头瘤病毒（HPV）通过性传播，可引发宫颈癌。尽管HPV可感染男性和女性，但人们对男性感染情况知之甚少。具体而言，特定类型HPV感染的患病率以及男性肛门生殖器解剖部位感染的分布情况尚未完全明确。
我们对463名年龄在18至40岁的男性进行了HPV检测，检测部位包括龟头/冠状沟、阴茎体、阴囊、尿道、肛周区域、肛管以及精液样本。符合条件的男性承认无尖锐湿疣病史，且在过去一年与女性有过性行为。对来自七个采样部位的每个标本进行PCR检测及针对37种类型的反向线印迹基因分型HPV检测。
若考虑任何采样部位的HPV检测结果，237名（51.2%）男性至少有一种致癌或非致癌HPV类型呈阳性，另有66名（14.3%）男性未分类HPV类型呈阳性。患病率最高的类型是HPV - 16（11.4%）和84型（10.6%）。外生殖器样本（龟头/冠状沟、阴茎体和阴囊）比肛门样本更有可能含有致癌HPV（25.1%对5.0%）。HPV阳性的阴茎体和龟头/冠状沟样本也比其他部位更有可能感染多种HPV类型。
更全面的肛门生殖器采样以及对37种HPV类型的灵敏检测，使得主要无症状男性的HPV患病率高于先前报道。阴茎体是最有可能HPV呈阳性的部位，且多种类型和致癌感染的比例最高。这些结果对男性HPV研究及性伴侣间传播具有启示意义。
