Oizumi Toshihide, Daimon Makoto, Jimbu Yumi, Kameda Wataru, Arawaka Nobuko, Yamaguchi Hiroshi, Ohnuma Hiroshi, Sasaki Hajime, Kato Takeo
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, Japan.
Tohoku J Exp Med. 2007 Jun;212(2):91-9. doi: 10.1620/tjem.212.91.
Palatinose is a disaccharide present in honey, which has the characteristics of delayed digestion and absorption. We developed a palatinose-based balanced formula (PBF) and reported its beneficial effects on metabolic syndrome-related parameters in rats. To examine the effects of PBF in humans, we here conducted a crossover study using twenty-three subjects with impaired glucose tolerance. The subjects were divided into two groups: intervention to control (I/C) and control to intervention (C/I) groups. The I/C group consumed PBF (250 kcal) together with foods that were 250 kcal less than their usual breakfast (intervention meal) for the first 12 weeks, followed by their usual breakfast (control meal) for the last 12 weeks. The protocol for the C/I group was opposite in order: the control meal for the first 12 weeks, followed by the intervention meal for the last 12 weeks. In the first 12-week period, the intervention meal decreased 2-hr plasma glucose levels after 75-g oral glucose tolerance test (-15.7 +/- 20.1% change), while the control meal did not (0.8 +/- 31.6% change). The difference between these changes was significant (p = 0.038). The similar results were obtained from the comparison of the changes between the first and the last 12-week periods in the two groups combined (intervention vs control: -11.8 +/- 22.5 vs 11.2 +/- 30.2% change, p = 0.024). PBF also had the beneficial effects on serum free fatty acids levels and visceral fat area. In conclusion, PBF consumption has beneficial effects on metabolic syndrome-related parameters in humans.
帕拉金糖是一种存在于蜂蜜中的二糖，具有消化和吸收延迟的特性。我们开发了一种基于帕拉金糖的平衡配方（PBF），并报道了其对大鼠代谢综合征相关参数的有益影响。为了研究PBF对人类的影响，我们在此对23名糖耐量受损的受试者进行了一项交叉研究。受试者被分为两组：干预组到对照组（I/C）和对照组到干预组（C/I）。I/C组在最初的12周内食用PBF（250千卡），同时食用比他们平常早餐少250千卡的食物（干预餐），在最后的12周食用他们平常的早餐（对照餐）。C/I组的方案顺序相反：最初12周食用对照餐，最后12周食用干预餐。在最初的12周期间，干预餐在75克口服葡萄糖耐量试验后降低了2小时血浆葡萄糖水平（变化-15.7±20.1%），而对照餐没有（变化0.8±31.6%）。这些变化之间的差异具有统计学意义（p = 0.038）。两组合并后，比较最初和最后12周期间的变化也得到了类似的结果（干预组与对照组：变化-11.8±22.5%与11.2±30.2%，p = 0.024）。PBF对血清游离脂肪酸水平和内脏脂肪面积也有有益影响。总之，食用PBF对人类代谢综合征相关参数有有益影响。
