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多功能线虫:秀丽隐杆线虫研究的遗传与基因组资源

The versatile worm: genetic and genomic resources for Caenorhabditis elegans research.

作者信息

Antoshechkin Igor, Sternberg Paul W

机构信息

Division of Biology 156-29, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA.

出版信息

Nat Rev Genet. 2007 Jul;8(7):518-32. doi: 10.1038/nrg2105. Epub 2007 Jun 5.

Abstract

Since its establishment as a model organism, Caenorhabditis elegans has been an invaluable tool for biological research. An immense spectrum of questions can be addressed using this small nematode, making it one of the most versatile and exciting model organisms. Although the many tools and resources developed by the C. elegans community greatly facilitate new discoveries, they can also overwhelm newcomers to the field. This Review aims to familiarize new worm researchers with the main resources, and help them to select the tools that are best suited for their needs. We also hope that it will be helpful in identifying new research opportunities and will promote the development of additional resources.

摘要

自秀丽隐杆线虫被确立为模式生物以来,它一直是生物学研究中不可或缺的工具。利用这种小型线虫可以解决广泛的问题,使其成为最多功能且最令人兴奋的模式生物之一。尽管秀丽隐杆线虫研究群体开发的众多工具和资源极大地促进了新发现,但它们也可能让该领域的新手应接不暇。本综述旨在让线虫研究新手熟悉主要资源,并帮助他们选择最适合自身需求的工具。我们还希望它有助于发现新的研究机会,并促进更多资源的开发。

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