Shrivastav Anuraag, Sharma Anil R, Bajaj Gagan, Charavaryamath Chandrashekhar, Ezzat Wendelin, Spafford Peter, Gore-Hickman Rick, Singh Baljit, Copete Maria A, Sharma Rajendra K
Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon S7N 5E5, Canada.
Oncol Rep. 2007 Jul;18(1):93-7.
N-myristoyltransferase (NMT) catalyzes the myristoylation of proteins involved in signal transduction, cellular transformation, differentiation, proliferation and oncogenesis. In this study, we report for the first time on the elevated NMT activity in oral squamous cell carcinoma (OSCC). Increased activity is marked with increased staining for NMT in the OSCC samples compared to the normal adjacent tissues. In addition, we observed increased staining for the N-myristoyltransferase inhibitor protein 71 (NIP71) in the OSCC samples compared to the control tissues. These findings suggest the regulatory relationship between NMT and NIP71 during tumorigenesis. It is possible that the increased activity results in the overexpression of NIP71 in an effort to control NMT activity.
N-肉豆蔻酰转移酶（NMT）催化参与信号转导、细胞转化、分化、增殖和肿瘤发生的蛋白质的肉豆蔻酰化。在本研究中，我们首次报道了口腔鳞状细胞癌（OSCC）中NMT活性升高。与相邻正常组织相比，OSCC样本中NMT活性增加表现为NMT染色增强。此外，与对照组织相比，我们观察到OSCC样本中N-肉豆蔻酰转移酶抑制蛋白71（NIP71）的染色增强。这些发现表明在肿瘤发生过程中NMT与NIP71之间存在调节关系。活性增加可能导致NIP71过表达，以努力控制NMT活性。
