Ye Lin, Kynaston Howard G, Jiang Wen G
Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, UK.
Int J Mol Med. 2007 Jul;20(1):103-11.
Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. The bony metastasis is incurable and contributes significantly to disease-specific morbidity and mortality. The molecular and cellular mechanisms leading to the development of bone metastasis in prostate cancer remain unclear, but are currently under intensive investigation. In this review, we summarized the current understanding of bone metastasis in prostate cancer. The rapid progress in the genetic predisposition that makes prostate cancer cells more prone to spread to bone, bone-derived factors which are involved in the development of bone metastasis at the level of the local microenvironment, the interactions between metastatic prostate cancer cells and bone marrow endothelial cells, osteoblasts, and osteoclasts, are discussed in this article.
前列腺癌是西方国家男性中最常见的癌症，骨转移发生率很高。骨转移无法治愈，且在很大程度上导致了疾病特异性的发病和死亡。导致前列腺癌骨转移发生的分子和细胞机制仍不清楚，但目前正在深入研究。在本综述中，我们总结了目前对前列腺癌骨转移的认识。本文讨论了使前列腺癌细胞更易扩散至骨的遗传易感性方面的快速进展、在局部微环境水平参与骨转移发生的骨源性因子、转移性前列腺癌细胞与骨髓内皮细胞、成骨细胞和破骨细胞之间的相互作用。
