Jang Anna C-C, Starz-Gaiano Michelle, Montell Denise J
Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA.
J Mammary Gland Biol Neoplasia. 2007 Sep;12(2-3):103-14. doi: 10.1007/s10911-007-9042-8.
Cell motility makes essential contributions to normal embryonic development and homeostasis. It is also thought to contribute in important ways to tumor metastasis. Because of this dual importance, cell migration has been extensively studied. The fruit fly Drosophila melanogaster has served as an important model organism for genetic analysis of many aspects of developmental biology, including cell migration. Here we describe the various types of cell movements that have been studied in detail, which represent models for epithelial-to-mesenchymal transition, transepithelial migration, inflammation, wound healing and invasion. We summarize what has been learned about the molecular control of cell migration from genetic studies in the fly. In addition, we describe recent efforts to model tumor metastasis directly in Drosophila by expressing oncogenes and/or mutating tumor suppressor genes. Together these studies suggest that Drosophila has much to offer as a model for varied aspects of tumor metastasis.
细胞运动对正常胚胎发育和体内平衡起着至关重要的作用。人们还认为它在肿瘤转移方面发挥着重要作用。由于其具有这种双重重要性，细胞迁移已得到广泛研究。果蝇已成为发育生物学诸多方面（包括细胞迁移）遗传分析的重要模式生物。在此，我们描述了已被详细研究的各种细胞运动类型，它们代表上皮 - 间充质转化、跨上皮迁移、炎症、伤口愈合和侵袭的模型。我们总结了从果蝇遗传研究中了解到的关于细胞迁移分子控制的知识。此外，我们描述了最近通过表达癌基因和/或使肿瘤抑制基因突变在果蝇中直接模拟肿瘤转移的研究工作。这些研究共同表明，果蝇作为肿瘤转移各个方面的模型具有很大的价值。
