硫胺素和乙二胺四乙酸对绵羊胆汁和尿液中铅排泄的影响。

The effects of thiamine and EDTA on biliary and urinary lead excretion in sheep.

作者信息

Olkowski A A, Gooneratne S R, Christensen D A

机构信息

Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada.

出版信息

Toxicol Lett. 1991 Dec;59(1-3):153-9. doi: 10.1016/0378-4274(91)90067-g.

DOI:10.1016/0378-4274(91)90067-g

PMID:1755021

Abstract

Relative efficacy of thiamine (B1) and/or calcium disodium ethylinediaminetetraacetate (EDTA) administration on lead (Pb) excretion via bile and urine was studied in Pb-loaded sheep. The sheep were administered B1 s.c., 75 mg/kg body wt., EDTA i.v., 110 mg/kg body wt., and a combination of B1-EDTA at rates as above. Each treatment was followed by 69 h sampling of blood, bile, and urine. Urinary Pb excretion increased following B1-EDTA greater than EDTA greater than B1 administration. Thiamine and B1-EDTA treatments increased biliary Pb excretion. Overall, B1, EDTA and B1-EDTA administration increased Pb excretion via bile and urine by 72%, 595%, and 842% respectively over basal level (mean +/- SE: 20.1 +/- 2.9 micrograms Pb/h). It has been concluded that thiamine enhances elimination of Pb from the body and this feature may be beneficial in chelation therapy.

摘要

在铅负荷的绵羊中研究了硫胺素（维生素B1）和/或乙二胺四乙酸二钠钙（EDTA）给药对经胆汁和尿液排出铅（Pb）的相对疗效。给绵羊皮下注射硫胺素，剂量为75毫克/千克体重，静脉注射EDTA，剂量为110毫克/千克体重，并以上述速率联合使用硫胺素 - EDTA。每次治疗后进行69小时的血液、胆汁和尿液采样。硫胺素 - EDTA给药后尿铅排泄增加，大于EDTA给药，大于硫胺素给药。硫胺素和硫胺素 - EDTA治疗增加了胆汁中铅的排泄。总体而言，与基础水平（平均±标准误：20.1±2.9微克铅/小时）相比，硫胺素、EDTA和硫胺素 - EDTA给药分别使经胆汁和尿液排出的铅增加了72%、595%和842%。得出的结论是，硫胺素可增强体内铅的消除，这一特性可能对螯合疗法有益。