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金属中毒中的螯合作用 XVIII：硫胺素和依地酸二钠钙对铅毒性的联合作用。

Chelation in metal intoxication XVIII: Combined effects of thiamine and calcium disodium versenate on lead toxicity.

作者信息

Flora S J, Singh S, Tandon S K

出版信息

Life Sci. 1986 Jan 6;38(1):67-71. doi: 10.1016/0024-3205(86)90276-6.

DOI:10.1016/0024-3205(86)90276-6
PMID:3079852
Abstract

Calcium disodium ethylenediaminetetraacetate (Ca-Na2EDTA; Versenate) was more effective than thiamine (vitamin B1) in enhancing the urinary excretion of lead, reducing tissue lead and restoring lead induced biochemical alterations in rats. However, the combination of CaNa2EDTA and vitamin B1 enhanced the beneficial effect of CaNa2EDTA in lead intoxication and was particularly effective in reducing the brain concentration of lead.

摘要

依地酸钙钠（Ca-Na2EDTA；乙磺半胱氨酸）在促进大鼠尿铅排泄、降低组织铅含量以及恢复铅诱导的生化改变方面比硫胺素（维生素B1）更有效。然而，CaNa2EDTA与维生素B1联合使用可增强CaNa2EDTA对铅中毒的有益作用，尤其在降低脑铅浓度方面效果显著。

相似文献

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Chelation in metal intoxication XVIII: Combined effects of thiamine and calcium disodium versenate on lead toxicity.金属中毒中的螯合作用 XVIII：硫胺素和依地酸二钠钙对铅毒性的联合作用。
Life Sci. 1986 Jan 6;38(1):67-71. doi: 10.1016/0024-3205(86)90276-6.
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引用本文的文献

1
Influence of dietary supplementation with thiamine on lead intoxication in rats.补充硫胺素对大鼠铅中毒的影响。
Biol Trace Elem Res. 1986 Aug;10(2):137-44. doi: 10.1007/BF02795566.
2
Chelation in metal intoxication.金属中毒的螯合作用。
Int J Environ Res Public Health. 2010 Jul;7(7):2745-88. doi: 10.3390/ijerph7072745. Epub 2010 Jun 28.
3
Influence of thiamine and ascorbic acid supplementation on the antidotal efficacy of thiol chelators in experimental lead intoxication.硫胺素和抗坏血酸补充剂对实验性铅中毒中硫醇螯合剂解毒效果的影响。
Arch Toxicol. 1988;62(4):301-4. doi: 10.1007/BF00332491.
4
Chelation in metal intoxication XXI: Chelation in lead intoxication during vitamin B complex deficiency.金属中毒中的螯合作用 XXI：复合维生素 B 缺乏时铅中毒的螯合作用
Bull Environ Contam Toxicol. 1986 Sep;37(3):317-25. doi: 10.1007/BF01607767.
5
Therapeutic efficacy of dimercaptosuccinic acid and thiamine/ascorbic acid on lead intoxication in rats.二巯基丁二酸和硫胺素/抗坏血酸对大鼠铅中毒的治疗效果
Bull Environ Contam Toxicol. 1989 Nov;43(5):705-12. doi: 10.1007/BF01701991.
6
The effects of thiamin on lead metabolism: organ distribution of lead 203.硫胺素对铅代谢的影响：铅203的器官分布
Can J Vet Res. 1992 Jul;56(3):256-9.