Sipetic Sandra, Vlajinac Hristina, Marinkovi Jelena, Kocev Nikola, Milan Bjekic, Ratkov Isidora, Sajic Silvija
Institute of Epidemiology, School of Medicine, Belgrade University, Serbia.
J Pediatr Endocrinol Metab. 2007 Apr;20(4):527-34. doi: 10.1515/jpem.2007.20.4.527.
To test the hypothesis that stressful life events and psychological dysfunction increase the risk for development of type 1 diabetes mellitus (DM1).
A case-control study comprising 105 children with DM1 and 210 controls matched by age +/- 1 year), sex and place of residence. Conditional univariate and multivariate logistic regressions were used to analyze the data.
After adjustment for possible confounders, the following factors were positively related to DM1: parents' job-related issues changed or lost job (odds ratio [OR] 11.5, 95% confidence interval [CI] 1.6-81.8); other severe life events--severe accident, hospitalization or death of close friend, quarrels between parents, war in republics of former Yugoslavia, near-drowning in a pool, falling down, unhurt participant of an accident (OR 68.5, 95% CI 13.5-349.0); other minor life events--conflicts with parents/teacher/neighbors, lost in town, physical attack, failure in competition, penalty, examination, death of pet, presence at lightning strike, thrown out of dwelling (OR 32.7, 95% CI 6.3-169.6); and learning problems (OR 17.5, 95% CI 4.3-71.6).
These results support the hypothesis that stressful life events and psychological dysfunctions are associated with DM1.
检验应激性生活事件和心理功能障碍会增加1型糖尿病（DM1）发病风险这一假设。
一项病例对照研究，纳入105例DM1患儿和210名对照，根据年龄（±1岁）、性别和居住地点进行匹配。采用条件单因素和多因素逻辑回归分析数据。
在对可能的混杂因素进行调整后，以下因素与DM1呈正相关：父母与工作相关的问题、更换工作或失业（比值比[OR]11.5，95%置信区间[CI]1.6 - 81.8）；其他严重生活事件——严重事故、亲密朋友住院或死亡、父母争吵、前南斯拉夫各共和国发生战争、在游泳池差点溺水、摔倒、未受伤的事故参与者（OR 68.5，95% CI 13.5 - 349.0）；其他轻微生活事件——与父母/老师/邻居发生冲突、在城镇迷路、身体攻击、比赛失败、受罚、考试、宠物死亡、遭遇雷击、被赶出住所（OR 32.7，95% CI 6.3 - 169.6）；以及学习问题（OR 17.5，95% CI 4.3 - 71.6）。
这些结果支持应激性生活事件和心理功能障碍与DM1相关的假设。
