贝尔格莱德儿童糖尿病研究：糖尿病风险决定因素的多变量分析

The Belgrade childhood diabetes study: a multivariate analysis of risk determinants for diabetes.

作者信息

Sipetić Sandra B, Vlajinac Hristina D, Kocev Nikola I, Marinković Jelena M, Radmanović Slobodan Z, Bjekić Milan D

机构信息

Institute of Epidemiology, School of Medicine, Belgrade University, Belgrade, Serbia and Montenegro.

出版信息

Eur J Public Health. 2005 Apr;15(2):117-22. doi: 10.1093/eurpub/cki074.

DOI:10.1093/eurpub/cki074

PMID:15941756

Abstract

BACKGROUND

The aim of this study was to evaluate some hypotheses about factors related to the development of type 1 diabetes mellitus.

METHODS

A case-control study was conducted in Belgrade during the period 1994-1997. A total of 105 recently onset diabetic and 210 control children, individually matched by age (+/-1 year), sex and place of residence, were included in the study.

RESULTS

According to multivariate regression analysis, the following factors were related to type 1 diabetes: stressful events and symptoms of psychological dysfunction during the 12 months preceding the onset of the disease [odds ratio (OR) 3.48, 95% confidence interval (CI) 2.15-5.65; and OR 2.15, 95% CI 1.33-3.48], irregular vaccination (OR 16.98, 95% CI 1.38-208.92), infection during 6 months preceding the onset of the disease (OR 4.23, 95% CI 1.95-9.17), higher education of father (OR 1.50, 95% CI 1.05-2.14), mother's consumption of nitrosoamines-rich food during pregnancy (OR 4.33, 95% CI 1.95-9.61), alcohol consumption by father (OR 3.80, 95% CI 1.64-8.78), insulin-dependent and non-insulin-dependent diabetes mellitus in three generations of children's relatives (OR 20.04, 95% CI 4.73-84.81; and OR 5.52, 95% CI 2.45-12.46), and use of ultrasound diagnostic techniques during pregnancy (OR 0.42, 95% CI 0.17-1.00).

CONCLUSIONS

Among non-genetic factors, those affecting the child during pregnancy are especially important because of their preventability.

摘要

背景

本研究的目的是评估一些关于1型糖尿病发病相关因素的假设。

方法

1994年至1997年期间在贝尔格莱德进行了一项病例对照研究。共有105名近期发病的糖尿病儿童和210名对照儿童纳入研究，这些儿童按年龄（±1岁）、性别和居住地进行个体匹配。

结果

根据多因素回归分析，以下因素与1型糖尿病相关：疾病发作前12个月内的应激事件和心理功能障碍症状[比值比（OR）3.48，95%置信区间（CI）2.15 - 5.65；以及OR 2.15，95% CI 1.33 - 3.48]、疫苗接种不规律（OR 16.98，95% CI 1.38 - 208.92）、疾病发作前6个月内的感染（OR 4.23，95% CI 1.95 - 9.17）、父亲受教育程度较高（OR 1.50，95% CI 1.05 - 2.14）、母亲孕期食用富含亚硝胺的食物（OR 4.33，95% CI 1.95 - 9.61）、父亲饮酒（OR 3.80，95% CI 1.64 - 8.78）、儿童三代亲属中有胰岛素依赖型和非胰岛素依赖型糖尿病（OR 20.04，95% CI 4.73 - 84.81；以及OR 5.52，95% CI 2.45 - 12.46），以及孕期使用超声诊断技术（OR 0.42，95% CI 0.17 - 1.00）。