Vlajinac Hristina, Sipetić Sandra, Marinković Jelena, Bjekić Milan, Kocev Nikola, Sajić Silvija
Institute of Epidemiology, School of Medicine, Belgrade University, Belgrade, Serbia and Montenegro.
Paediatr Perinat Epidemiol. 2006 May;20(3):238-43. doi: 10.1111/j.1365-3016.2006.00713.x.
A case-control study was conducted in Belgrade (about 320,000 inhabitants 0-16 years old) during the period 1994-97, comprising 68 diabetic children (cases) and 68 controls chosen from the siblings of the cases. Analysis using multivariable logistic regression analysis indicated the following independent risk factors for Type 1 diabetes: higher birth order, infections during the 6 months preceding the onset of the disease and stressful events. Out of individual stressful and psychological factors, 'other' stressful events (severe accident or hospitalisation or death of a close friend, conflict with a teacher, death of a pet, failure in competition, quarrel between parents, punishment, physical attack, war in republics of former Yugoslavia and near drowning in the pool) and learning problems were independent risk factor for Type 1 diabetes. The results obtained in this study of siblings supports the hypothesis that environmental factors play a role in the development of Type 1 diabetes.
1994年至1997年期间，在贝尔格莱德（约有32万0至16岁居民）开展了一项病例对照研究，研究对象包括68名糖尿病儿童（病例组）以及从病例组儿童的兄弟姐妹中选取的68名对照。采用多变量逻辑回归分析进行分析后发现，1型糖尿病的独立危险因素如下：出生顺序较高、发病前6个月内发生感染以及遭遇应激事件。在个体应激和心理因素中，“其他”应激事件（严重事故、住院、密友死亡、与老师发生冲突、宠物死亡、比赛失利、父母争吵、惩罚、身体攻击、前南斯拉夫各共和国发生战争以及在泳池中险些溺水）和学习问题是1型糖尿病的独立危险因素。这项针对兄弟姐妹开展的研究所得出的结果支持了环境因素在1型糖尿病发病过程中起作用这一假说。
