Tomokuni K, Ichiba M, Hirai Y
Department of Community Health Science, Saga Medical School, Japan.
Toxicol Lett. 1991 Dec;59(1-3):169-73. doi: 10.1016/0378-4274(91)90069-i.
Urinary excretion of beta-aminoisobutyric acid (ABA) and delta-aminolevulinic acid (ALA) was investigated in mice exposed to lead (500 p.p.m.) in drinking water for 14 days. Concentrations of both urinary ABA and urinary ALA increased significantly in the lead-exposed mice. However, the degree of increasing excretion was higher in urinary ALA (10-fold of the control) than in urinary ABA (2-fold of the control). On the other hand, it was demonstrated that ALA dehydratase in liver and kidney is inhibited by exposure to lead, while ALA synthase in these tissues has no inhibitory effect.
对饮用含铅（500 ppm）水14天的小鼠的β-氨基异丁酸（ABA）和δ-氨基乙酰丙酸（ALA）的尿排泄情况进行了研究。在接触铅的小鼠中，尿ABA和尿ALA的浓度均显著增加。然而，ALA排泄增加的程度在尿ALA中（是对照组的10倍）高于尿ABA中（是对照组的2倍）。另一方面，已证明肝脏和肾脏中的ALA脱水酶会因接触铅而受到抑制，而这些组织中的ALA合酶没有抑制作用。
