Tomokuni K, Ichiba M, Hirai Y
Department of Community Health Science, Saga Medical School, Japan.
Int Arch Occup Environ Health. 1993;65(1):19-21. doi: 10.1007/BF00586053.
To examine the relationships between the urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and beta-aminoisobutyric acid (AIBA) as a metabolite of thymine, and exposure to chromium, nickel, and iron, we determined these parameters in 58 workers engaged in the cutting and grinding of stainless steel or iron-steel plates. A significant increase in urinary NAG activity or urinary AIBA excretion was found in some of these workers. However, we could not find a significant positive correlation between the urinary excretion of NAG or AIBA and the urinary concentration of chromium, nickel, or iron as an indicator of internal dose.
为了研究作为胸腺嘧啶代谢产物的N-乙酰-β-D-氨基葡萄糖苷酶（NAG）和β-氨基异丁酸（AIBA）的尿排泄量与铬、镍和铁暴露之间的关系，我们测定了58名从事不锈钢或钢铁板材切割和研磨工作的工人的这些参数。在其中一些工人中发现尿NAG活性或尿AIBA排泄量显著增加。然而，作为体内剂量指标，我们未发现NAG或AIBA的尿排泄量与尿中铬、镍或铁浓度之间存在显著正相关。
