Moody D E, Narloch B A, Shull L R, Hammock B D
Department of Entomology, University of California, Davis.
Toxicol Lett. 1991 Dec;59(1-3):175-85. doi: 10.1016/0378-4274(91)90070-m.
Male mice were treated with structurally diverse herbicides to study their effect on liver xenobiotic-metabolizing enzymes. Chlorfiurecol, trifluralin, alachlor, propham, MCPP and 2,4-DP caused increases in phase I (cytochrome P-450, ethoxycoumarin O-deethylase, and/or aminopyrine N-demethylase) and phase II (microsomal epoxide hydrolase and cytosolic glutathione S-transferase) activities. MCPP and 2,4-DP also increased cytosolic epoxide hydrolase and carnitine acetyltransferase activities suggestive of peroxisome proliferation. Benthiocarb and molinate increased only some phase II enzyme activities. Dicamba, at the dose employed, caused mortality and decreases in some of the enzymes monitored. Most of the herbicides tested induced xenobiotic-metabolizing enzyme activities, the pattern of induction being dependent on herbicide structure.
用结构多样的除草剂处理雄性小鼠，以研究它们对肝脏异生物质代谢酶的影响。氯氟草醚、氟乐灵、甲草胺、苯胺灵、灭草灵和2,4-滴丙酸导致I相（细胞色素P-450、乙氧香豆素O-脱乙基酶和/或氨基比林N-脱甲基酶）和II相（微粒体环氧化物水解酶和胞质谷胱甘肽S-转移酶）活性增加。灭草灵和2,4-滴丙酸还增加了胞质环氧化物水解酶和肉碱乙酰转移酶的活性，提示过氧化物酶体增殖。杀草丹和禾草特仅增加了一些II相酶的活性。所使用剂量的麦草畏导致死亡，并使一些监测的酶活性降低。大多数测试的除草剂诱导了异生物质代谢酶的活性，诱导模式取决于除草剂的结构。
