敌草隆和绿麦隆（两种取代苯基脲类除草剂）对大鼠肝脏药物代谢酶的剂量相关诱导作用。

Dose-related induction of rat hepatic drug-metabolizing enzymes by diuron and chlorotoluron, two substituted phenylurea herbicides.

作者信息

Schoket B, Vincze I

机构信息

Department of Biochemistry, National Institute of Hygiene, Budapest, Hungary.

出版信息

Toxicol Lett. 1990 Jan;50(1):1-7. doi: 10.1016/0378-4274(90)90246-i.

DOI:10.1016/0378-4274(90)90246-i

PMID:2104995

Abstract

Dose-related induction of various hepatic drug-metabolizing enzymes has been investigated after short-term treatment of rats by diuron and chlorotoluron, a dichlorinated and a monochlorinated phenylurea herbicide, respectively. Results suggest that 'saturation' of the induction system of benzo(a)pyrene monooxygenase, 7-ethoxycoumarin O-deethylase and 7-ethoxyresorufin O-deethylase activities may occur in the same range of the molar doses of both compounds, and with the dichlorinated herbicide at much higher activities. Induction of epoxide hydrolase, UDP-glucuronyltransferase and glutathione S-transferases also shows saturation curves in the function of molar doses. However, the structural difference is not reflected in the enhancement of enzyme activities.

摘要

分别用敌草隆和绿麦隆（一种二氯苯基脲除草剂和一种一氯苯基脲除草剂）对大鼠进行短期治疗后，研究了各种肝药代谢酶的剂量相关诱导作用。结果表明，苯并(a)芘单加氧酶、7-乙氧基香豆素O-脱乙基酶和7-乙氧基试卤灵O-脱乙基酶活性的诱导系统“饱和”可能在两种化合物的相同摩尔剂量范围内出现，且二氯除草剂的活性要高得多。环氧水解酶、UDP-葡萄糖醛酸基转移酶和谷胱甘肽S-转移酶的诱导在摩尔剂量的作用下也呈现饱和曲线。然而，结构差异并未反映在酶活性的增强上。