曲酸的致突变性研究。
Mutagenicity studies of kojic acid.
作者信息
Wei C I, Huang T S, Fernando S Y, Chung K T
机构信息
Food Science and Human Nutrition Department, University of Florida, Gainesville 32611-0163.
出版信息
Toxicol Lett. 1991 Dec;59(1-3):213-20. doi: 10.1016/0378-4274(91)90074-g.
Kojic acid, a fungal metabolite produced by some species of Aspergillus and Penicillium, was found to induce sister chromatid exchanges and chromosomal aberrations in Chinese hamster ovary cells in the presence or absence of the rat liver S9 mix. Furthermore, this compound was demonstrated to induce mutations in Salmonella typhimurium strains TA98 and TA100 using both plate-incorporation and preincubation methods.
曲酸是由某些曲霉属和青霉属真菌产生的一种代谢产物，研究发现，无论有无大鼠肝脏S9混合液存在，曲酸均可诱导中国仓鼠卵巢细胞发生姐妹染色单体交换和染色体畸变。此外，采用平板掺入法和预孵育法，均证明该化合物可诱导鼠伤寒沙门氏菌TA98和TA100菌株发生突变。
Zotero 插件