两种阴道米索前列醇方案用于管理妊娠16周以内终止妊娠的随机试验。
A randomised trial of two regimens of vaginal misoprostol to manage termination of pregnancy of up to 16 weeks.
作者信息
Khazardoost Soghra, Hantoushzadeh Sedigheh, Madani Marjan Moezi
机构信息
Perinatalogy Department, Vali-e-Asr Reproductive Health Research Centre, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Aust N Z J Obstet Gynaecol. 2007 Jun;47(3):226-9. doi: 10.1111/j.1479-828X.2007.00721.x.
OBJECTIVE
The purpose of this study was to compare the efficacy and side-effects of two regimens of vaginal misoprostol for pregnancy termination of up to 16 weeks.
METHODS
A randomised clinical trial of medical pregnancy termination of up to 16 weeks was conducted. A hundred pregnant women requesting legal termination of pregnancy were randomised into two groups to receive either 200 microg (50 women) or 400 microg (50 women)--vaginal misoprostol every six hours up to four doses. Outcome of abortion and side-effects were assessed.
RESULTS
The groups were similar in maternal age, gestational age, parity and indication for pregnancy termination. There were no statistically significant differences between the two groups in abortion (P = 0.084) and mean induction to abortion time (P = 0.35). However, the side-effects in the 400 microg group were significantly higher than in the 200 microg group (P = 0.000).
CONCLUSION
In pregnancy termination of up to 16 weeks, 200 microg vaginal misoprostol every six hours up to four doses was as effective as 400 microg, but side-effects were more common in 400 microg regimen.
目的
本研究旨在比较两种阴道米索前列醇方案用于终止16周以内妊娠的疗效和副作用。
方法
开展一项针对16周以内妊娠药物流产的随机临床试验。100名要求合法终止妊娠的孕妇被随机分为两组，分别接受200微克（50名妇女）或400微克（50名妇女）阴道米索前列醇，每6小时一次，最多4剂。评估流产结局和副作用。
结果
两组在产妇年龄、孕周、产次和终止妊娠指征方面相似。两组在流产方面（P = 0.084）和平均引产至流产时间方面（P = 0.35）无统计学显著差异。然而，400微克组的副作用显著高于200微克组（P = 0.000）。
结论
在终止16周以内妊娠时，每6小时一次给予200微克阴道米索前列醇，最多4剂，与400微克的效果相同，但400微克方案的副作用更常见。
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