Mensinger Allen F, Powers Maureen K
Vision Research Center and Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Vis Neurosci. 2007 May-Jun;24(3):299-307. doi: 10.1017/S0952523807070265. Epub 2007 May 29.
Regeneration of the teleost retina following surgical extirpation of 25% to 100% of the neural retina was investigated in goldfish (Carrasius auratus) and sunfish (Lepomis cyanellus). The retina will regenerate following removal of up to 95% of the neural retina, however complete extirpation prevented regeneration. Visual sensitivity was assessed by examining components of the electroretinogram (ERG) and the dorsal light reflex (DLR) during regeneration. B-wave amplitudes in the experimental eyes increased throughout the study and central connections were reestablished as indicated by the progressive improvement in the dorsal light reflex. The recovery of visual function was closely correlated with retinal regeneration. Visual recovery progressed more slowly than following complete cytotoxic destruction of the mature retina (Mensinger & Powers, 1999) because the surgery removed a large number of the pluripotent cell population and restricted the number and distribution of regenerating foci.
在金鱼（Carassius auratus）和翻车鱼（Lepomis cyanellus）中研究了手术切除25%至100%神经视网膜后硬骨鱼视网膜的再生情况。切除高达95%的神经视网膜后，视网膜会再生，然而完全切除则会阻止再生。在再生过程中，通过检查视网膜电图（ERG）和背侧光反射（DLR）的成分来评估视觉敏感性。在整个研究过程中，实验眼的B波振幅增加，并且背侧光反射的逐渐改善表明中枢连接得以重新建立。视觉功能的恢复与视网膜再生密切相关。视觉恢复的进展比成熟视网膜完全细胞毒性破坏后要慢（Mensinger & Powers，1999），因为手术移除了大量多能细胞群体，并限制了再生灶的数量和分布。
