Fukino Y, Ikeda A, Maruyama K, Aoki N, Okubo T, Iso H
Department of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Suruga-ku, Shizuoka-shi, Japan.
Eur J Clin Nutr. 2008 Aug;62(8):953-60. doi: 10.1038/sj.ejcn.1602806. Epub 2007 Jun 6.
We examined whether green tea-extract powder supplementation improves glucose abnormality.
The study was conducted for volunteers who resided in eastern communities of Shizuoka Prefecture and who had fasting blood glucose levels of >or=6.1 mmol/l or nonfasting blood glucose levels of >or=7.8 mmol/l in a recent health check-up. Sixty subjects aged 32-73 years (49 males and 11 females) participated in the trial. The Early intervention group consumed a packet of green tea-extract powder containing 544 mg polyphenols (456 mg catechins) daily for the first 2 months and then entered the 2-month nonintervention period. The Later intervention group was observed for the first 2 months and then consumed green tea-extract powder as described above for the subsequent 2 months. Using the two-period crossover design, we analyzed the changes in fasting hemoglobin A1c level and other biomarkers in blood samples collected at baseline, 2 months and 4 months.
A significant reduction in hemoglobin A1c level and a borderline significant reduction in diastolic blood pressure were associated with the intervention. The intervention caused no significant changes in weight, body mass index, body fat, systolic blood pressure, fasting serum glucose level, homeostasis model assessment index, serum lipid level or hypersensitive C-reactive protein.
Daily supplementary intake of green tea-extract powder lowered the hemoglobin A1c level in individuals with borderline diabetes.
我们研究了补充绿茶提取物粉末是否能改善血糖异常情况。
该研究针对居住在静冈县东部社区、在最近一次健康检查中空腹血糖水平≥6.1 mmol/l或非空腹血糖水平≥7.8 mmol/l的志愿者开展。60名年龄在32至73岁之间的受试者（49名男性和11名女性）参与了试验。早期干预组在最初2个月每天服用一包含有544毫克多酚（456毫克儿茶素）的绿茶提取物粉末，然后进入2个月的非干预期。后期干预组在最初2个月进行观察，随后的2个月按上述方法服用绿茶提取物粉末。采用两阶段交叉设计，我们分析了在基线、2个月和4个月时采集的血样中空腹糖化血红蛋白水平及其他生物标志物的变化。
干预与糖化血红蛋白水平显著降低以及舒张压临界显著降低相关。干预对体重、体重指数、体脂、收缩压、空腹血清葡萄糖水平、稳态模型评估指数、血脂水平或超敏C反应蛋白均未产生显著变化。
每日补充绿茶提取物粉末可降低临界糖尿病个体的糖化血红蛋白水平。
