Schulz Cornelia, Ritzmann Mathias, Palzer Andreas, Heinritzi Karl, Zöls Susanne
Klinik für Schweine, Ludwig-Maximilians-Universität München.
Berl Munch Tierarztl Wochenschr. 2007 May-Jun;120(5-6):177-82.
Since April 2006 piglets in Germany can only be castrated without anesthesia in the first 7 days of life. However, a castration is a painful experience even for an animal of this young age. Whether the castration under isoflurane-anesthesia is a reasonable alternative to castration without anesthesia was tested in the following investigation at 206 4 to 6 day old piglets. The serum-cortisol-concentration was chosen as the parameter for the pain caused by castration. A part of the animals was castrated without anesthesia (group II, n = 42) or with anesthesia (group IV, n = 41). Additionally Meloxicam, a non-steroidal anti-inflammatory drug, was applicated to piglets castrated with anesthesia (group V, n = 41). For control another part of the animals were only handled without (group I, n = 41) or with anesthesia (group III, n = 41), but they were not castrated. Cortisol-concentration prior to castration was compared to the concentration 0.5, 1,4 and 24 hours after castration. In addition cortisol was compared between groups at all points of time. Cortisol did rise significantly in castrated animals with animals with or without anesthesia than in animals of the non-castrated control groups. Cortisol after castration was significantly lower in piglets with an application of Meloxicam prior to castration. The pain caused by castration is an explanation for the differences in cortisol-concentration between castrated and not-castrated animals. Regarding those results, we assume that castration with isoflurane-anesthesia does not fulfil the demand for reducing pain after castration compared to castrating piglets without anesthesia.
自2006年4月起，德国的仔猪只有在出生后的头7天才能在无麻醉的情况下进行阉割。然而，即使对于如此年幼的动物来说，阉割也是一种痛苦的经历。在以下对206头4至6日龄仔猪的研究中，测试了异氟烷麻醉下的阉割是否是无麻醉阉割的合理替代方法。选择血清皮质醇浓度作为阉割引起疼痛的参数。一部分动物在无麻醉的情况下进行阉割（第二组，n = 42）或在有麻醉的情况下进行阉割（第四组，n = 41）。此外，将一种非甾体抗炎药美洛昔康应用于在有麻醉情况下阉割的仔猪（第五组，n = 41）。作为对照，另一部分动物仅在无麻醉（第一组，n = 41）或有麻醉（第三组，n = 41）的情况下进行处理，但不进行阉割。将阉割前的皮质醇浓度与阉割后0.5、1、4和24小时的浓度进行比较。此外，还在所有时间点对各组之间的皮质醇进行了比较。与未阉割的对照组动物相比，无论有无麻醉，阉割后的动物皮质醇均显著升高。在阉割前应用美洛昔康的仔猪中，阉割后的皮质醇显著降低。阉割引起的疼痛解释了阉割动物与未阉割动物之间皮质醇浓度的差异。基于这些结果，我们认为与无麻醉阉割仔猪相比，异氟烷麻醉下的阉割不能满足减少阉割后疼痛的要求。
