Lambert Jamil, Nakano Tatsuya, Law Sue, Elsey Justin, McKenzie David R, Suchowerska Natalka
School of Physics, The University of Sydney, NSW 2006 Australia.
Med Phys. 2007 May;34(5):1759-65. doi: 10.1118/1.2727248.
The large dose gradients in brachytherapy necessitate a detector with a small active volume for accurate dosimetry. The dosimetric performance of a novel scintillation detector (BrachyFOD) is evaluated and compared to three commercially available detectors, a diamond detector, a MOSFET, and LiF TLDs. An 192Ir HDR brachytherapy source is used to measure the depth dependence, angular dependence, and temperature dependence of the detectors. Of the commercially available detectors, the diamond detector was found to be the most accurate, but has a large physical size. The TLDs cannot provide real time readings and have depth dependent sensitivity. The MOSFET used in this study was accurate to within 5% for distances of 20 to 50 mm from the 192Ir source in water but gave errors of 30%-40% for distances greater than 50 mm from the source. The BrachyFOD was found to be accurate to within 3% for distances of 10 to 100 mm from an HDR 192Ir brachytherapy source in water. It has an angular dependence of less than 2% and the background signal created by Cerenkov radiation and fluorescence of the plastic optical fiber is insignificant compared to the signal generated in the scintillator. Of the four detectors compared in this study the BrachyFOD has the most favorable combination of characteristics for dosimetry in HDR brachytherapy.
近距离放射治疗中的大剂量梯度要求使用具有小有效体积的探测器以进行精确的剂量测定。对一种新型闪烁探测器(BrachyFOD)的剂量学性能进行了评估,并与三种市售探测器(金刚石探测器、MOSFET和LiF热释光剂量计)进行了比较。使用铱-192高剂量率近距离放射治疗源来测量探测器的深度依赖性、角度依赖性和温度依赖性。在市售探测器中,金刚石探测器被发现是最精确的,但物理尺寸较大。热释光剂量计不能提供实时读数,且具有深度依赖性灵敏度。本研究中使用的MOSFET在水中距离铱-192源20至50毫米处的测量精度在5%以内,但在距离源大于50毫米处的误差为30%-40%。在水中距离铱-192高剂量率近距离放射治疗源10至100毫米处,BrachyFOD的测量精度在3%以内。其角度依赖性小于2%,并且与闪烁体中产生的信号相比,由切伦科夫辐射和塑料光纤荧光产生的背景信号微不足道。在本研究中比较的四种探测器中,BrachyFOD在高剂量率近距离放射治疗剂量测定方面具有最有利的综合特性。