Martins de Lima Thais, Gorjão Renata, Hatanaka Elaine, Cury-Boaventura Maria Fernanda, Portioli Silva Erica Paula, Procopio Joaquim, Curi Rui
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Clin Sci (Lond). 2007 Jul;113(2):65-77. doi: 10.1042/CS20070006.
Fatty acids (FAs) have been shown to alter leucocyte function and thus to modulate inflammatory and immune responses. In this review, the effects of FAs on several aspects of lymphocyte, neutrophil and macrophage function are discussed. The mechanisms by which FAs modulate the production of lipid mediators, activity of intracellular signalling pathways, activity of lipid-raft-associated proteins, binding to TLRs (Toll-like receptors), control of gene expression, activation of transcription factors, induction of cell death and production of reactive oxygen and nitrogen species are described in this review. The rationale for the use of specific FAs to treat patients with impaired immune function is explained. Substantial improvement in the therapeutic usage of FAs or FA derivatives may be possible based on an improvement in the understanding of the precise molecular mechanisms of action with respect to the different leucocyte types and outcome with respect to the inflammatory responses.
脂肪酸（FAs）已被证明可改变白细胞功能，从而调节炎症和免疫反应。在本综述中，讨论了脂肪酸对淋巴细胞、中性粒细胞和巨噬细胞功能多个方面的影响。本综述描述了脂肪酸调节脂质介质产生、细胞内信号通路活性、脂筏相关蛋白活性、与Toll样受体（TLRs）结合、基因表达控制、转录因子激活、细胞死亡诱导以及活性氧和氮物种产生的机制。解释了使用特定脂肪酸治疗免疫功能受损患者的基本原理。基于对不同白细胞类型精确分子作用机制以及炎症反应结果理解的改善，脂肪酸或脂肪酸衍生物的治疗应用可能会有实质性改进。
