Papanikolaou Evangelos G, Kolibianakis Efstratios M, Pozzobon Cristina, Tank Parikshit, Tournaye Herman, Bourgain Claire, Van Steirteghem Andre, Devroey Paul
Centre for Reproductive Medicine, University Hospital, Vrije Univestiteit Brussel, Free University of Brussels, Brussels, Belgium.
Fertil Steril. 2009 Mar;91(3):949-52. doi: 10.1016/j.fertnstert.2006.12.064. Epub 2007 Jun 6.
Four hundred eighty-two patients undergoing single ET with GnRH-antagonist/recFSH protocol were analyzed. The incidence of premature luteinization (P above 1.5 ng/mL on the day of hCG administration) was 18.2%. Even modest rises of P in the follicular phase have detrimental effect on the implantation potential of a good-quality cleavage stage embryo. On the contrary, premature luteinization in the blastocyst subgroup had no effect on the pregnancy outcome.
对482例行单次胚胎移植且采用促性腺激素释放激素拮抗剂/重组促卵泡素方案的患者进行了分析。过早黄素化（人绒毛膜促性腺激素给药当天孕酮高于1.5 ng/mL）的发生率为18.2%。即使在卵泡期孕酮有适度升高也会对优质卵裂期胚胎的着床潜力产生不利影响。相反，胚泡亚组中的过早黄素化对妊娠结局没有影响。
