猿猴水痘病毒基因组包含一个665个碱基对的可倒置末端元件，而水痘带状疱疹病毒基因组中不存在该元件。
The simian varicella virus genome contains an invertible 665 base pair terminal element that is absent in the varicella zoster virus genome.
作者信息
Mahalingam Ravi, Gray Wayne L
机构信息
Department of Neurology, Mail Box B183, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA.
出版信息
Virology. 2007 Sep 30;366(2):387-93. doi: 10.1016/j.virol.2007.04.030. Epub 2007 Jun 6.
Simian varicella virus (SVV) causes chickenpox in monkeys, establishes latency and reactivates to produce zoster thus providing a model to study human varicella zoster virus (VZV) infection. Sequence analysis of a recombinant cosmid clone containing the left end of the SVV genome revealed a 665 base pair (bp) segment that is absent in VZV DNA. This segment inverts and contains 507 bp of unique sequences flanked on either side by 79 bp inverted repeats, making the SVV genome to be 124,785 bp in size. Part of the inverted repeat sequence (64 bp) is also present at the junction of the long and short segments of the SVV genome. The terminal DNA sequences are conserved among different SVV isolates and present in tissues from infected monkeys. The terminal region is transcriptionally active and is also present in the genomes of other animal varicelloviruses but absent in the VZV genome.
猴水痘病毒（SVV）可在猴子中引起水痘，建立潜伏感染并重新激活产生带状疱疹，从而为研究人类水痘带状疱疹病毒（VZV）感染提供了一个模型。对一个包含SVV基因组左端的重组黏粒克隆进行序列分析，发现了一段665个碱基对（bp）的片段，该片段在VZV DNA中不存在。该片段发生倒位，包含507 bp的独特序列，两侧各有79 bp的反向重复序列，使SVV基因组大小为124,785 bp。部分反向重复序列（64 bp）也存在于SVV基因组的长片段和短片段的交界处。末端DNA序列在不同的SVV分离株中保守，并且存在于受感染猴子的组织中。末端区域具有转录活性，也存在于其他动物水痘病毒的基因组中，但在VZV基因组中不存在。
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