Shapiro Lee A, Ng Kwan L, Zhou Qun-Yong, Ribak Charles E
Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697-1275, USA.
Neuroreport. 2007 Jul 2;18(10):981-5. doi: 10.1097/WNR.0b013e3281532bc1.
Neurogenesis persists in the adult rodent olfactory epithelium and olfactory bulbs. Recent studies suggest that neurogenesis might also occur in the adult rodent piriform cortex, the primary cortical projection site of the olfactory bulbs. To determine whether olfactory enrichment influences neurogenesis in the mouse piriform cortex, olfactory enrichment was used in combination with bromodeoxyuridine labeling. Quantification of the number of bromodeoxyuridine-labeled cells in the piriform cortex that double label for either the immature neuronal marker, doublecortin, or the mature neuronal marker, neuronal nuclei or NeuN, showed that olfactory enrichment increases the survival of newborn neurons in the piriform cortex. These results confirm that neurogenesis occurs in the piriform cortex of rodents and suggest that it may play a neuroplastic role there.
神经发生在成年啮齿动物的嗅上皮和嗅球中持续存在。最近的研究表明，神经发生也可能发生在成年啮齿动物的梨状皮质，即嗅球的主要皮质投射部位。为了确定嗅觉富集是否会影响小鼠梨状皮质中的神经发生，将嗅觉富集与溴脱氧尿苷标记结合使用。对梨状皮质中溴脱氧尿苷标记的细胞数量进行定量分析，这些细胞对未成熟神经元标记物双皮质素或成熟神经元标记物神经元细胞核或NeuN进行双重标记，结果表明嗅觉富集可提高梨状皮质中新生神经元的存活率。这些结果证实了神经发生发生在啮齿动物的梨状皮质中，并表明它可能在那里发挥神经可塑性作用。
