Shapiro Lee A, Ng Kwan, Zhou Qun-Yong, Ribak Charles E
Department of Surgery and Neurosurgery, Texas A&M University College of Medicine, Temple, TX 76504, USA.
Epilepsy Behav. 2009 Jan;14 Suppl 1(Suppl 1):74-80. doi: 10.1016/j.yebeh.2008.09.011. Epub 2008 Oct 26.
Neurogenesis persists in several regions of the adult mammalian brain. Although the hippocampus and olfactory bulb are most commonly studied in the context of adult neurogenesis, there is an increasing body of evidence in support of neurogenesis occurring outside of these two regions. The current study expands on previous data by showing newborn neurons with a mature phenotype are located in several olfactory and limbic structures outside of the hippocampus and olfactory bulb, where we previously described doublecortin/bromodeoxyuridine immature neurons. Notably, newborn neurons with a mature neuronal phenotype are found in the olfactory tubercles, anterior olfactory nuclei, tenia tecta, islands of Calleja, amygdala, and lateral entorhinal cortex. The appearance of newborn neurons with a mature phenotype in these regions suggests that these structures are destinations, and that newborn neurons are not simply passing through these structures. In light of the increasing body of evidence for neurogenesis in these and other olfactory, limbic, and striatal structures, we hypothesize that brain regions displaying adult neurogenesis are functionally linked.
神经发生在成年哺乳动物大脑的多个区域持续存在。虽然海马体和嗅球在成年神经发生的背景下是最常被研究的，但越来越多的证据支持在这两个区域之外也发生神经发生。当前的研究通过显示具有成熟表型的新生神经元位于海马体和嗅球之外的几个嗅觉和边缘结构中，扩展了先前的数据，我们之前在这些结构中描述了双皮质素/溴脱氧尿苷未成熟神经元。值得注意的是，在嗅结节、前嗅核、终纹床核、Calleja岛、杏仁核和外侧内嗅皮质中发现了具有成熟神经元表型的新生神经元。这些区域中具有成熟表型的新生神经元的出现表明这些结构是目的地，并且新生神经元并非只是简单地穿过这些结构。鉴于在这些以及其他嗅觉、边缘和纹状体结构中神经发生的证据越来越多，我们假设显示成年神经发生的脑区在功能上是相互联系的。
