Zeise Marc L, Espinoza Sergio, González Adolfo, Cerda Fernanda S, Nacarate Judith, Yáñez Cesar G, Morales Bernardo
Faculty of Humanities, School of Psychology, University of Santiago de Chile, Chile.
Neuroreport. 2007 Jul 2;18(10):1059-62. doi: 10.1097/WNR.0b013e32819f8f3f.
Despite its still rapidly increasing use in the treatment of the attention deficit/hyperactivity disorder, the effects of methylphenidate on behavior and learning are not yet fully understood. We have used the Morris water maze to study effects of methylphenidate (1 mg/kg) on target-oriented behavior and visuospatial learning in young rats. Although the relatively low dose of 1 mg/kg methylphenidate changed the behavior in the Morris water maze when the goal was visible, reducing times to reach the visible platform, learning of the position of the hidden platform, was not influenced, nor was 'relearning' after shifting the position of the platform. These results indicate that methylphenidate can influence goal-oriented behavior at doses that do not change visuospatial learning.
尽管哌甲酯在治疗注意力缺陷/多动障碍方面的使用仍在迅速增加，但其对行为和学习的影响尚未完全明确。我们使用莫里斯水迷宫研究了哌甲酯（1毫克/千克）对幼鼠目标导向行为和视觉空间学习的影响。当目标可见时，虽然相对低剂量（1毫克/千克）的哌甲酯改变了莫里斯水迷宫中的行为，减少了到达可见平台的时间，但隐藏平台位置的学习未受影响，平台位置改变后的“重新学习”也未受影响。这些结果表明，哌甲酯在不改变视觉空间学习的剂量下可影响目标导向行为。
