Chang Myung Chul, Douglas William H
School of Material Science and Chemical Engineering, Kunsan National University, Kunsan 573-701, Korea.
J Mater Sci Mater Med. 2007 Oct;18(10):2045-51. doi: 10.1007/s10856-007-3152-0. Epub 2007 Jun 9.
Hydroxyapatite [HAp]/Gelatin [GEL] nanocomposite was prepared at 37 and 48 degrees C through coprecipitation process. The HAp/GEL nanocomposite slurries were cross-linked by imide-based zero-length cross-linking agent such as N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide (EDC) and N-hydroxysuccinimide (NHS). The chemical bond formation and microstructure in HAp/GEL nanocomposite was investigated as a function of cross-linking agents and temperature. The single addition of EDC into the composite slurries resulted in a tougher microstructure in both samples prepared at 37 and 48 degrees C. However, in the case of the simultaneous addition of EDC and NHS the sample prepared at 48 degrees C showed a coarse microstructure. These results were consistent with the fact that the chemical reactivity of NHS is degraded at 48 degrees C whereas the reactivity of EDC increases up to 80 degrees C.
通过共沉淀法在37和48摄氏度下制备了羟基磷灰石[HAp]/明胶[GEL]纳米复合材料。HAp/GEL纳米复合浆料通过基于酰亚胺的零长度交联剂如N-(3-二甲基氨基丙基)-N'-乙基碳二亚胺(EDC)和N-羟基琥珀酰亚胺(NHS)进行交联。研究了HAp/GEL纳米复合材料中化学键的形成和微观结构与交联剂和温度的关系。在37和48摄氏度制备的两种样品中，向复合浆料中单独添加EDC都会导致更致密的微观结构。然而，在同时添加EDC和NHS的情况下，48摄氏度制备的样品显示出粗大的微观结构。这些结果与NHS在48摄氏度时化学反应性降低而EDC的反应性在高达80摄氏度时增加这一事实一致。
