Gregoret L M, Rader S D, Fletterick R J, Cohen F E
Department of Pharmaceutical Chemistry, University of California, San Francisco 94143-0446.
Proteins. 1991;9(2):99-107. doi: 10.1002/prot.340090204.
Intrachain hydrogen bonds are a hallmark of globular proteins. Traditionally, these involve oxygen and nitrogen atoms. The electronic structure of sulfur is compatible with hydrogen bond formation as well. We surveyed a set of 85 high-resolution protein structures in order to evaluate the prevalence and geometry of sulfur-containing hydrogen bonds. This information should be of interest to experimentalists and theoreticians interested in protein structure and protein engineering.
链内氢键是球状蛋白质的一个标志。传统上，这些氢键涉及氧原子和氮原子。硫的电子结构也与氢键形成兼容。我们研究了一组85个高分辨率蛋白质结构，以评估含硫氢键的普遍性和几何结构。这些信息对于对蛋白质结构和蛋白质工程感兴趣的实验人员和理论人员应该是有意义的。
