Mestecky J, Eldridge J H
University of Alabama, Birmingham.
Curr Opin Immunol. 1991 Aug;3(4):492-5. doi: 10.1016/0952-7915(91)90009-p.
Increased awareness of the fact that the mucosal membranes are the portals of entry for the majority of infectious agents, and that antibodies in external secretions often correlate better with protection than do corresponding antibodies in serum, has prompted many recent studies aimed at the selective induction of antibodies in mucosal secretions. The recent development of novel technologies (expression of antigens in various microbial vectors that colonize mucosal surfaces and incorporation of antigens in biodegradable microspheres) indicate that the goal of vaccination with enhanced induction of both mucosal and systemic immune responses is attainable.
人们越来越意识到，粘膜是大多数感染因子的进入门户，而且外分泌液中的抗体往往比血清中的相应抗体与保护作用的相关性更好，这促使最近开展了许多旨在选择性诱导粘膜分泌物中抗体的研究。新技术的最新发展（在定殖于粘膜表面的各种微生物载体中表达抗原以及将抗原掺入可生物降解的微球中）表明，增强粘膜和全身免疫反应诱导的疫苗接种目标是可以实现的。
