Norton P M, Le Page R W, Wells J M
Department of Pathology, University of Cambridge, UK.
Folia Microbiol (Praha). 1995;40(3):225-30. doi: 10.1007/BF02814197.
The non-pathogenic, non-colonising Gram-positive organism Lactobacillus lactis is beeing developed as an antigen delivery system for mucosal vaccination. A high level expression system has been developed which allows loading of the bacterium with high levels of a heterologous antigen (TTFC) prior to inoculation. Mucosal inoculation of one such recombinant strain results in a protective serum antibody response and production of TTFC-specific IgA at mucosal sites.
非致病性、非定植性革兰氏阳性菌乳酸乳球菌正被开发用作黏膜疫苗接种的抗原递送系统。已开发出一种高效表达系统，该系统能使细菌在接种前负载高水平的异源抗原（TTFC）。对一种这样的重组菌株进行黏膜接种会引发保护性血清抗体反应，并在黏膜部位产生TTFC特异性IgA。
