Sweiss Nadera J, Curran James, Baughman Robert P
Section of Rheumatology & Immunology, University of Chicago, Chicago, IL 60637, USA.
Clin Dermatol. 2007 May-Jun;25(3):341-6. doi: 10.1016/j.clindermatol.2007.03.012.
Tumor necrosis factor is a potent cytokine involved in the inflammatory process of many diseases. Agents that block tumor necrosis factor have been used in the treatment of various immune-mediated diseases, including rheumatoid arthritis, Crohn disease, psoriatic arthritis, and ankylosing spondylitis. Sarcoidosis is an immune-mediated inflammatory disorder of unknown etiology characterized by the formation of noncaseating granulomas. Tumor necrosis factor plays a major role in the inflammatory process seen in sarcoidosis. Sarcoidosis therapies with activity against tumor necrosis factor and specific anti-tumor necrosis factor therapies have been used with variable success. The long-term safety and efficacy of such therapies are yet to be determined in well-designed clinical trials with long-term follow-up.
肿瘤坏死因子是一种强效细胞因子，参与多种疾病的炎症过程。阻断肿瘤坏死因子的药物已被用于治疗各种免疫介导的疾病，包括类风湿性关节炎、克罗恩病、银屑病关节炎和强直性脊柱炎。结节病是一种病因不明的免疫介导的炎症性疾病，其特征是形成非干酪样肉芽肿。肿瘤坏死因子在结节病的炎症过程中起主要作用。具有抗肿瘤坏死因子活性的结节病治疗方法以及特定的抗肿瘤坏死因子治疗方法的使用效果各不相同。此类治疗方法的长期安全性和有效性尚有待在设计良好且有长期随访的临床试验中确定。
