University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.
University of Texas Southwestern Medical Center, Department of Anesthesiology and Pain Management, D, United States.
J Biomed Opt. 2019 Jan;24(5):1-11. doi: 10.1117/1.JBO.24.5.051409.
Diffuse optical tomography has demonstrated significant potential for clinical utility in the diagnosis and prognosis of breast cancer, and its use in combination with other structural imaging modalities improves lesion localization and the quantification of functional tissue properties. Here, we introduce a hybrid diffuse optical imaging system that operates concurrently with magnetic resonance imaging (MRI) in the imaging suite, utilizing commercially available MR surface coils. The instrument acquires both continuous-wave and time-domain diffuse optical data in the parallel-plate geometry, permitting both absolute assignment of tissue optical properties and three-dimensional tomography; moreover, the instrument is designed to incorporate diffuse correlation spectroscopic measurements for probing tissue blood flow. The instrument is described in detail here. Image reconstructions of a tissue phantom are presented as an initial indicator of the system's ability to accurately reconstruct optical properties and the concrete benefits of the spatial constraints provided by concurrent MRI. Last, we briefly discuss how various data combinations that the instrument could facilitate, including tissue perfusion, can enable more comprehensive assessment of lesion physiology.
漫射光学断层成像技术在乳腺癌的诊断和预后方面具有重要的临床应用潜力，其与其他结构成像方式的结合可以提高病变的定位和功能组织特性的量化。在这里，我们介绍了一种混合式漫射光学成像系统，该系统可在影像套件中与磁共振成像（MRI）同时运行，利用市售的磁共振表面线圈。该仪器采用平行板几何结构，同时采集连续波和时域漫射光学数据，允许对组织光学特性进行绝对赋值和三维层析成像；此外，该仪器设计用于纳入漫射相关光谱测量，以探测组织血流。这里详细描述了该仪器。我们展示了组织体模的图像重建，作为系统准确重建光学特性的初始指标，以及由并行 MRI 提供的空间约束的具体优势。最后，我们简要讨论了该仪器可以促进的各种数据组合，包括组织灌注，这可以实现对病变生理学的更全面评估。
