Das Mini, Xu Chen, Zhu Quing
Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269, USA.
Appl Opt. 2006 Jul 10;45(20):5027-36. doi: 10.1364/ao.45.005027.
Reflectance measurement of breast tissue is influenced by the underlying chest wall, which is often tilted as seen by the detection probe. We develop an analytical solution of light propagation in a two-layer tissue structure with tilted interface and refractive index difference between the layers. We validate the analytical solution with Monte Carlo simulations and phantom experiments, and a good agreement is seen. The influence of varying the tilting angle of the interface on the reflectance is discussed for two types of layered structures. Further, we apply the developed analytical solution to obtain the optical properties of breast tissue and chest wall from clinical data. Inverse calculation using the developed solution applied to the data obtained from Monte Carlo simulations shows that the optical properties of both layers are obtained with higher accuracy as compared to using a simple two-layer model ignoring the interface tilt. This is expected to improve the accuracy in estimating the optical properties of breast tissue, thus enhancing the accuracy of optical tomography of breast tumors.
乳腺组织的反射率测量会受到下方胸壁的影响，从检测探头看，胸壁通常是倾斜的。我们针对具有倾斜界面且各层间存在折射率差异的双层组织结构，推导出了光传播的解析解。我们通过蒙特卡罗模拟和体模实验对该解析解进行了验证，结果显示二者吻合良好。针对两种类型的分层结构，讨论了界面倾斜角度变化对反射率的影响。此外，我们应用所推导的解析解，从临床数据中获取乳腺组织和胸壁的光学特性。将所推导的解应用于从蒙特卡罗模拟获得的数据进行反演计算表明，与使用忽略界面倾斜的简单双层模型相比，两层的光学特性能够以更高的精度获得。这有望提高乳腺组织光学特性估计的准确性，从而提高乳腺肿瘤光学层析成像的准确性。
