暴露细胞色素bc1复合体Qo位点半醌自由基。
Exposing the complex III Qo semiquinone radical.
作者信息
Zhang Haibo, Osyczka Artur, Dutton P Leslie, Moser Christopher C
机构信息
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Biochim Biophys Acta. 2007 Jul;1767(7):883-7. doi: 10.1016/j.bbabio.2007.04.004. Epub 2007 May 1.
Abstract
Complex III Qo site semiquinone has been assigned pivotal roles in productive energy-conversion and destructive superoxide generation. After a 30-year search, a genetic heme bH knockout arrests this transient semiquinone EPR radical, revealing the natural engineering balance pitting energy-conserving, short-circuit minimizing, split electron transfer and catalytic speed against damaging oxygen reduction.
摘要
细胞色素bc1复合体Qo位点半醌在有效的能量转换和有害的超氧生成中都发挥着关键作用。经过30年的探索，基因敲除血红素bH可捕获这种短暂的半醌EPR自由基，揭示了自然工程学上的平衡，即节能、短路最小化、电子传递分离、催化速度与有害的氧还原之间的权衡。
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