Lang Undine E, Hellweg Rainer, Seifert Frank, Schubert Florian, Gallinat Juergen
Department of Psychiatry and Psychotherapy, Charité-University Medicine Berlin, Campus Mitte, Berlin, Germany.
Biol Psychiatry. 2007 Sep 1;62(5):530-5. doi: 10.1016/j.biopsych.2007.01.002. Epub 2007 Jun 8.
Brain-derived neurotrophic factor (BDNF) signaling at synapses improves synaptic strengthening associated with learning and memory. In the present study we hypothesized that serum BDNF concentration is associated with in vivo level of cerebral N-acetylaspartate (NAA), a well established marker of neuronal integrity.
In 36 healthy subjects BDNF serum concentration and absolute concentration of NAA together with other metabolites were measured by proton magnetic resonance spectroscopy (1H-MRS) in regions with high BDNF levels (anterior cingulate cortex [ACC], left hippocampus). Relationship between BDNF concentration and brain metabolites was studied in linear regression analysis with BDNF concentration as dependent variable and metabolite concentrations, age, and gender as predictor variables.
The BDNF serum concentrations were positively associated with the concentrations of NAA (T = 2.193, p = .037) and total choline (T = 1.997, p = .055; trend) but not total creatine or glutamate in the ACC. No significant association was observed between BDNF serum concentration and absolute metabolite concentrations in the hippocampus.
The preliminary data might indicate that BDNF serum concentration reflects some aspects of neuronal plasticity as indicated by its association with NAA level in the cerebral cortex. The results would be in line with the notion that BDNF plays a central role in the regulation of neuronal survival and differentiation in the human brain.
突触处脑源性神经营养因子（BDNF）信号传导可改善与学习和记忆相关的突触强化。在本研究中，我们假设血清BDNF浓度与脑N-乙酰天门冬氨酸（NAA）的体内水平相关，NAA是一种成熟的神经元完整性标志物。
对36名健康受试者，通过质子磁共振波谱（1H-MRS）在BDNF水平较高的区域（前扣带回皮质[ACC]、左侧海马体）测量BDNF血清浓度、NAA的绝对浓度以及其他代谢物。以BDNF浓度为因变量，代谢物浓度、年龄和性别为预测变量，通过线性回归分析研究BDNF浓度与脑代谢物之间的关系。
BDNF血清浓度与ACC中NAA的浓度呈正相关（T = 2.193，p = .037）以及总胆碱呈正相关（T = 1.997，p = .055；趋势），但与总肌酸或谷氨酸不相关。在海马体中，未观察到BDNF血清浓度与代谢物绝对浓度之间存在显著关联。
初步数据可能表明，BDNF血清浓度反映了神经元可塑性的某些方面，这一点可通过其与大脑皮质中NAA水平的关联得到证明。这些结果与BDNF在人类大脑神经元存活和分化调节中起核心作用的观点一致。
